EP300-interacting inhibitor of differentiation 2 (EID-2) (CREBBP/EP300 inhibitor 2) (EID-1-like inhibitor of differentiation 2)
1_MSKLP 6_ ADSSV 11_ PQTGA 16_ ANGDR 21_ DVPQA 26_ EVGRG 31_ RREPA 36_ PAQPE 41_ EAGEG 46_ AMAAA 51_ RGGPV 56_ PAARE 61_ GRMAA 66_ ARAAP 71_ AAAAR 76_ GAPVA 81_ AAALA 86_ RAAAA 91_ GRESP 96_ AAAAA 101_ REARM 106_ AEVAR 111_ LLGEP 116_ VDEEG 121_ PEGRP 126_ RSRHG 131_ NGGLA 136_ ALPYL 141_ RLRHP 146_ LSVLG 151_ INYQQ 156_ FLRHY 161_ LENYP 166_ IAPGR 171_ IQELE 176_ ERRRR 181_ FVEAC 186_ RAREA 191_ AFDAE 196_ YQRNP 201_ HRVDL 206_ DILTF 211_ TIALT 216_ ASEVI 221_ NPLIE 226_ ELGCD 231_KFINR
1: Interacts with EP300 and acts as a repressor of MYOD-dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex