Transmembrane protein 251
1_MPKPP 6_ DYSEL 11_ SDSLT 16_ LAVGT 21_ GRFSG 26_ PLHRA 31_ WRMMN 36_ FRQRM 41_ GWIGV 46_ GLYLL 51_ ASAAA 56_ FYYVF 61_ EISET 66_ YNRLA 71_ LEHIQ 76_ QHPEE 81_ PLEGT 86_ TWTHS 91_ LKAQL 96_ LSLPF 101_ WVWTV 106_ IFLVP 111_ YLQMF 116_ LFLYS 121_ CTRAD 126_ PKTVG 131_ YCIIP 136_ ICLAV 141_ ICNRH 146_ QAFVK 151_ ASNQI 156_SRLQL
1: Required for mannose-6-phosphate-dependent trafficking of lysosomal enzymes (PubMed:36074821, PubMed:36074822, PubMed:36096887). LYSET bridges GlcNAc-1-phosphate transferase (GNPTAB), to the membrane-bound transcription factor site-1 protease (MBTPS1), thus allowing proteolytic activation of the GNPTAB. GNPTAB is involved in the regulation of M6P-dependent Golgi-to-lysosome trafficking of lysosomal enzymes (PubMed:36074821, PubMed:36074822, PubMed:36096887). LYSET is thus an essential factor for maturation and delivery of lysosomal hydrolases (PubMed:36074822)
2: (Microbial infection) Essential for infection by muliple viruses, including SARS-CoV-2, that utilize activated cathepsins for entry after M6P-dependent lysosomal transport