Protein KASH5 (Coiled-coil domain-containing protein 155) (KASH domain-containing protein 5)
1_MDLPE 6_ GPVGG 11_ PTAEM 16_ YLRER 21_ PEEAR 26_ LGMPV 31_ SLEEQ 36_ ILNST 41_ FEACD 46_ PQRTG 51_ TVAVA 56_ QVLAY 61_ LEAVT 66_ GQGPQ 71_ DARLQ 76_ TLANS 81_ LDPNG 86_ EGPKA 91_ TVDLD 96_ TFLVV 101_ MRDWI 106_ AACQL 111_ HGGLE 116_ LEEET 121_ AFQGA 126_ LTSRQ 131_ LPSGC 136_ PEAEE 141_ PANLE 146_ SFGGE 151_ DPRPE 156_ LQATA 161_ DLLSS 166_ LEDLE 171_ LSNRR 176_ LVGEN 181_ AKLQR 186_ SMETA 191_ EEGSA 196_ RLGEE 201_ ILALR 206_ KQLHS 211_ TQQAL 216_ QFAKA 221_ MDEEL 226_ EDLKT 231_ LARSL 236_ EEQNR 241_ SLLAQ 246_ ARQAE 251_ KEQQH 256_ LVAEM 261_ ETLQE 266_ ENGKL 271_ LAERD 276_ GVKKR 281_ SQELA 286_ MEKDT 291_ LKRQL 296_ FECEH 301_ LICQR 306_ DTILS 311_ ERTRD 316_ VESLA 321_ QTLEE 326_ YRVTT 331_ QELRL 336_ EISRL 341_ EEQLS 346_ QTYEG 351_ PDELP 356_ EGAQL 361_ RRVGW 366_ TELLP 371_ PSLGL 376_ EIEAI 381_ RQKQE 386_ VATAD 391_ LSNPL 396_ CGVWQ 401_ WEEVI 406_ HETSE 411_ ETEFP 416_ SEAPA 421_ GGQRN 426_ FQGEP 431_ AHPEE 436_ GRKEP 441_ SMWLT 446_ RREEE 451_ EDAES 456_ QVTAD 461_ LPVPL 466_ GAPRP 471_ GDIPE 476_ NPPER 481_ PARRE 486_ LQQAL 491_ VPVMK 496_ KLVPV 501_ RRRAW 506_ GQLCL 511_ PPQRL 516_ RVTRH 521_ PLIPA 526_ PVLGL 531_ LLLLL 536_ LSVLL 541_ LGPSP 546_ PPTWP 551_ HLQLC 556_YLQPP
1: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis (PubMed:35587281). Required for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis (PubMed:35587281). Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation