Keratinocyte-associated protein 2 (KCP-2) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2) (Oligosaccharyl transferase subunit KCP2)
1_MVVGT 6_ GTSLA 11_ LSSLL 16_ SLLLF 21_ AGMQM 26_ YSRQL 31_ ASTEW 36_ LTIQG 41_ GLLGS 46_ GLFVF 51_ SLTAF 56_ NNLEN 61_ LVFGK 66_ GFQAK 71_ IFPEI 76_ LLCLL 81_ LALFA 86_ SGLIH 91_ RVCVT 96_ TCFIF 101_ SMVGL 106_ YYINK 111_ ISSTL 116_ YQAAA 121_ PVLTP 126_ AKVTG 131_KSKKR
1: Subunit of STT3A-containing oligosaccharyl transferase (OST-A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:22467853, PubMed:28860277). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER) (PubMed:22467853, PubMed:28860277). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex (PubMed:28860277). May be involved in N-glycosylation of APP (amyloid-beta precursor protein) (PubMed:21768116). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1 (PubMed:21768116)