Deubiquitinase OTUD6B (EC 3.4.19.12) (DUBA-5) (OTU domain-containing protein 6B)
1_MEAVL 6_ TEELD 11_ EEEQL 16_ LRRHR 21_ KEKKE 26_ LQAKI 31_ QGMKN 36_ AVPKN 41_ DKKRR 46_ KQLTE 51_ DVAKL 56_ EKEME 61_ QKHRE 66_ ELEQL 71_ KLTTK 76_ ENKID 81_ SVAVN 86_ ISNLV 91_ LENQP 96_ PRISK 101_ AQKRR 106_ EKKAA 111_ LEKER 116_ EERIA 121_ EAEIE 126_ NLTGA 131_ RHMES 136_ EKLAQ 141_ ILAAR 146_ QLEIK 151_ QIPSD 156_ GHCMY 161_ KAIED 166_ QLKEK 171_ DCALT 176_ VVALR 181_ SQTAE 186_ YMQSH 191_ VEDFL 196_ PFLTN 201_ PNTGD 206_ MYTPE 211_ EFQKY 216_ CEDIV 221_ NTAAW 226_ GGQLE 231_ LRALS 236_ HILQT 241_ PIEII 246_ QADSP 251_ PIIVG 256_ EEYSK 261_ KPLIL 266_ VYMRH 271_ AYGLG 276_ EHYNS 281_ VTRLV 286_NIVTE
1: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334). May also play a role in proteasome assembly and function (PubMed:28343629)
2: Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability