Acyl-coenzyme A diphosphatase FITM2 (EC 3.6.1.-) (Fat storage-inducing transmembrane protein 2) (Fat-inducing protein 2)
1_MEHLE 6_ RCEWL 11_ LRGTL 16_ VRAAV 21_ RRYLP 26_ WALVA 31_ SMLAG 36_ SLLKE 41_ LSPLP 46_ ESYLS 51_ NKRNV 56_ LNVYF 61_ VKVAW 66_ AWTFC 71_ LLLPF 76_ IALTN 81_ YHLTG 86_ KAGLV 91_ LRRLS 96_ TLLVG 101_ TAIWY 106_ ICTSI 111_ FSNIE 116_ HYTGS 121_ CYQSP 126_ ALEGV 131_ RKEHQ 136_ SKQQC 141_ HQEGG 146_ FWHGF 151_ DISGH 156_ SFLLT 161_ FCALM 166_ IVEEM 171_ SVLHE 176_ VKTDR 181_ SHCLH 186_ TAITT 191_ LVVAL 196_ GILTF 201_ IWVLM 206_ FLCTA 211_ VYFHN 216_ LSQKV 221_ FGTLF 226_ GLLSW 231_ YGTYG 236_ FWYPK 241_ AFSPG 246_ LPPQS 251_ CSLNL 256_KQDSY
1: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity) (PubMed:32915949). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates such as oleoyl-CoA/(9Z)-octadecenoyl-CoA and arachidonoyl-CoA/(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA in the endoplasmic reticulum (ER) lumen (By similarity) (PubMed:32915949). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity) (PubMed:18160536, PubMed:32915949). Directly binds to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity) (PubMed:21834987)