CD177 antigen (Human neutrophil alloantigen 2a) (HNA-2a) (NB1 glycoprotein) (NB1 GP) (Polycythemia rubra vera protein 1) (PRV-1) (CD antigen CD177)
1_MSAVL 6_ LLALL 11_ GFILP 16_ LPGVQ 21_ ALLCQ 26_ FGTVQ 31_ HVWKV 36_ SDLPR 41_ QWTPK 46_ NTSCD 51_ SGLGC 56_ QDTLM 61_ LIESG 66_ PQVSL 71_ VLSKG 76_ CTEAK 81_ DQEPR 86_ VTEHR 91_ MGPGL 96_ SLISY 101_ TFVCR 106_ QEDFC 111_ NNLVN 116_ SLPLW 121_ APQPP 126_ ADPGS 131_ LRCPV 136_ CLSME 141_ GCLEG 146_ TTEEI 151_ CPKGT 156_ THCYD 161_ GLLRL 166_ RGGGI 171_ FSNLR 176_ VQGCM 181_ PQPGC 186_ NLLNG 191_ TQEIG 196_ PVGMT 201_ ENCNR 206_ KDFLT 211_ CHRGT 216_ TIMTH 221_ GNLAQ 226_ EPTDW 231_ TTSNT 236_ EMCEV 241_ GQVCQ 246_ ETLLL 251_ LDVGL 256_ TSTLV 261_ GTKGC 266_ STVGA 271_ QNSQK 276_ TTIHS 281_ APPGV 286_ LVASY 291_ THFCS 296_ SDLCN 301_ SASSS 306_ SVLLN 311_ SLPPQ 316_ AAPVP 321_ GDRQC 326_ PTCVQ 331_ PLGTC 336_ SSGSP 341_ RMTCP 346_ RGATH 351_ CYDGY 356_ IHLSG 361_ GGLST 366_ KMSIQ 371_ GCVAQ 376_ PSSFL 381_ LNHTR 386_ QIGIF 391_ SAREK 396_ RDVQP 401_ PASQH 406_ EGGGA 411_ EGLES 416_ LTWGV 421_ GLALA 426_ PALWW 431_GVVCP
1: In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369)