ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)
1_MASPR 6_ TRKVL 11_ KEVRV 16_ QDENN 21_ VCFEC 26_ GAFNP 31_ QWVSV 36_ TYGIW 41_ ICLEC 46_ SGRHR 51_ GLGVH 56_ LSFVR 61_ SVTMD 66_ KWKDI 71_ ELEKM 76_ KAGGN 81_ AKFRE 86_ FLESQ 91_ EDYDP 96_ CWSLQ 101_ EKYNS 106_ RAAAL 111_ FRDKV 116_ VALAE 121_ GREWS 126_ LESSP 131_ AQNWT 136_ PPQPR 141_ TLPSM 146_ VHRVS 151_ GQPQS 156_ VTASS 161_ DKAFE 166_ DWLND 171_ DLGSY 176_ QGAQG 181_ NRYVG 186_ FGNTP 191_ PPQKK 196_ EDDFL 201_ NNAMS 206_ SLYSG 211_ WSSFT 216_ TGASR 221_ FASAA 226_ KEGAT 231_ KFGSQ 236_ ASQKA 241_ SELGH 246_ SLNEN 251_ VLKPA 256_ QEKVK 261_ EGKIF 266_ DDVSS 271_ GVSQL 276_ ASKVQ 281_ GVGSK 286_ GWRDV 291_ TTFFS 296_ GKAEG 301_ PLDSP 306_ SEGHS 311_ YQNSG 316_ LDHFQ 321_ NSNID 326_ QSFWE 331_ TFGSA 336_ EPTKT 341_ RKSPS 346_ SDSWT 351_ CADTS 356_ TERRS 361_ SDSWE 366_ VWGSA 371_ STNRN 376_ SNSDG 381_ GEGGE 386_ GTKKA 391_ VPPAV 396_ PTDDG 401_WDNQN
1: GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity)