G-protein coupled receptor 161 (G-protein coupled receptor RE2)
1_MSLNS 6_ SLSCR 11_ KELSN 16_ LTEEE 21_ GGEGG 26_ VIITQ 31_ FIAII 36_ VITIF 41_ VCLGN 46_ LVIVV 51_ TLYKK 56_ SYLLT 61_ LSNKF 66_ VFSLT 71_ LSNFL 76_ LSVLV 81_ LPFVV 86_ TSSIR 91_ REWIF 96_ GVVWC 101_ NFSAL 106_ LYLLI 111_ SSASM 116_ LTLGV 121_ IAIDR 126_ YYAVL 131_ YPMVY 136_ PMKIT 141_ GNRAV 146_ MALVY 151_ IWLHS 156_ LIGCL 161_ PPLFG 166_ WSSVE 171_ FDEFK 176_ WMCVA 181_ AWHRE 186_ PGYTA 191_ FWQIW 196_ CALFP 201_ FLVML 206_ VCYGF 211_ IFRVA 216_ RVKAR 221_ KVHCG 226_ TVVIV 231_ EEDAQ 236_ RTGRK 241_ NSSTS 246_ TSSSG 251_ SRRNA 256_ FQGVV 261_ YSANQ 266_ CKALI 271_ TILVV 276_ LGAFM 281_ VTWGP 286_ YMVVI 291_ ASEAL 296_ WGKSS 301_ VSPSL 306_ ETWAT 311_ WLSFA 316_ SAVCH 321_ PLIYG 326_ LWNKT 331_ VRKEL 336_ LGMCF 341_ GDRYY 346_ REPFV 351_ QRQRT 356_ SRLFS 361_ ISNRI 366_ TDLGL 371_ SPHLT 376_ ALMAG 381_ GQPLG 386_ HSSST 391_ GDTGF 396_ SCSQD 401_ SGTDM 406_ MLLED 411_ YTSDD 416_ NPPSH 421_ CTCPP 426_ KRRSS 431_ VTFED 436_ EVEQI 441_ KEAAK 446_ NSILH 451_ VKAEV 456_ HKSLD 461_ SYAAS 466_ LAKAI 471_ EAEAK 476_ INLFG 481_ EEALP 486_ GVLVT 491_ ARTVP 496_ GGGFG 501_ GRRGS 506_ RTLVS 511_ QRLQL 516_ QSIEE 521_GDVLA
1: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity)