ER membrane protein complex subunit 1
1_MAAEW 6_ ASRFW 11_ LWATL 16_ LIPAA 21_ AVYED 26_ QVGKF 31_ DWRQQ 36_ YVGKV 41_ KFASL 46_ EFSPG 51_ SKKLV 56_ VATEK 61_ NVIAA 66_ LNSRT 71_ GEILW 76_ RHVDK 81_ GTAEG 86_ AVDAM 91_ LLHGQ 96_ DVITV 101_ SNGGR 106_ IMRSW 111_ ETNIG 116_ GLNWE 121_ ITLDS 126_ GSFQA 131_ LGLVG 136_ LQESV 141_ RYIAV 146_ LKKTT 151_ LALHH 156_ LSSGH 161_ LKWVE 166_ HLPES 171_ DSIHY 176_ QMVYS 181_ YGSGV 186_ VWALG 191_ VVPFS 196_ HVNIV 201_ KFNVE 206_ DGEIV 211_ QQVRV 216_ STPWL 221_ QHLSG 226_ ACGVV 231_ DEAVL 236_ VCPDP 241_ SSRSL 246_ QTLAL 251_ ETEWE 256_ LRQIP 261_ LQSLD 266_ LEFGS 271_ GFQPR 276_ VLPTQ 281_ PNPVD 286_ ASRAQ 291_ FFLHL 296_ SPSHY 301_ ALLQY 306_ HYGTL 311_ SLLKN 316_ FPQTA 321_ LVSFA 326_ TTGEK 331_ TVAAV 336_ MACRN 341_ EVQKS 346_ SSSED 351_ GSMGS 356_ FSEKS 361_ SSKDS 366_ LACFN 371_ QTYTI 376_ NLYLV 381_ ETGRR 386_ LLDTT 391_ ITFSL 396_ EQSGT 401_ RPERL 406_ YIQVF 411_ LKKDD 416_ SVGYR 421_ ALVQT 426_ EDHLL 431_ LFLQQ 436_ LAGKV 441_ VLWSR 446_ EESLA 451_ EVVCL 456_ EMVDL 461_ PLTGA 466_ QAELE 471_ GEFGK 476_ KADGL 481_ LGMFL 486_ KRLSS 491_ QLILL 496_ QAWTS 501_ HLWKM 506_ FYDAR 511_ KPRSQ 516_ IKNEI 521_ NIDTL 526_ ARDEF 531_ NLQKM 536_ MVMVT 541_ ASGKL 546_ FGIES 551_ SSGTI 556_ LWKQY 561_ LPNVK 566_ PDSSF 571_ KLMVQ 576_ RTTAH 581_ FPHPP 586_ QCTLL 591_ VKDKE 596_ SGMSS 601_ LYVFN 606_ PIFGK 611_ WSQVA 616_ PPVLK 621_ RPILQ 626_ SLLLP 631_ VMDQD 636_ YAKVL 641_ LLIDD 646_ EYKVT 651_ AFPAT 656_ RNVLR 661_ QLHEL 666_ APSIF 671_ FYLVD 676_ AEQGR 681_ LCGYR 686_ LRKDL 691_ TTELS 696_ WELTI 701_ PPEVQ 706_ RIVKV 711_ KGKRS 716_ SEHVH 721_ SQGRV 726_ MGDRS 731_ VLYKS 736_ LNPNL 741_ LAVVT 746_ ESTDA 751_ HHERT 756_ FIGIF 761_ LIDGV 766_ TGRII 771_ HSSVQ 776_ KKAKG 781_ PVHIV 786_ HSENW 791_ VVYQY 796_ WNTKA 801_ RRNEF 806_ TVLEL 811_ YEGTE 816_ QYNAT 821_ AFSSL 826_ DRPQL 831_ PQVLQ 836_ QSYIF 841_ PSSIS 846_ AMEAT 851_ ITERG 856_ ITSRH 861_ LLIGL 866_ PSGAI 871_ LSLPK 876_ ALLDP 881_ RRPEI 886_ PTEQS 891_ REENL 896_ IPYSP 901_ DVQIH 906_ AERFI 911_ NYNQT 916_ VSRMR 921_ GIYTA 926_ PSGLE 931_ STCLV 936_ VAYGL 941_ DIYQT 946_ RVYPS 951_ KQFDV 956_ LKDDY 961_ DYVLI 966_ SSVLF 971_ GLVFA 976_ TMITK 981_ RLAQV 986_KLLNR
1: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable)