Kelch domain-containing protein 1
1_MADSQ 6_ LFCVA 11_ EERSG 16_ HCAVV 21_ DGNFL 26_ YVWGG 31_ YVSIE 36_ DNEVY 41_ LPNDE 46_ IWTYD 51_ IDSGL 56_ WRMHL 61_ MEGEL 66_ PASMS 71_ GSCGA 76_ CINGK 81_ LYIFG 86_ GYDDK 91_ GYSNR 96_ LYFVN 101_ LRTRD 106_ ETYIW 111_ EKITD 116_ FEGQP 121_ PTPRD 126_ KLSCW 131_ VYKDR 136_ LIYFG 141_ GYGCR 146_ RHSEL 151_ QDCFD 156_ VHDAS 161_ WEEQI 166_ FWGWH 171_ NDVHI 176_ FDTKT 181_ QTWFQ 186_ PEIKG 191_ GVPPQ 196_ PRAAH 201_ TCAVL 206_ GNKGY 211_ IFGGR 216_ VLQTR 221_ MNDLH 226_ YLNLD 231_ TWTWS 236_ GRITI 241_ NGESP 246_ KHRSW 251_ HTLTP 256_ IADDK 261_ LFLCG 266_ GLSAD 271_ NIPLS 276_ DGWIH 281_ NVTTN 286_ CWKQL 291_ THLPK 296_ TRPRL 301_ WHTAC 306_ LGKEN 311_ EIMVF 316_ GGSKD 321_ DLLAL 326_ DTGHC 331_ NDLLI 336_ FQTQP 341_ YSLLR 346_ SCLDC 351_ IGKNS 356_ IMLES 361_ QISLL 366_ PPKLL 371_ QQVLK 376_ KITFW 381_ AAANH 386_ REEQR 391_ VQKEE 396_ TENKY 401_QWISS
1: Substrate-recognition component of a Cul5-RING (CRL5) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:32200094). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:32200094). The CRL5(KLHDC1) complex mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine (PubMed:32200094)