HORMA domain-containing protein 2
1_MATAQ 6_ LSHCI 11_ TIHKA 16_ SKETV 21_ FPSQI 26_ TNEHE 31_ SLKMV 36_ KKLFA 41_ TSISC 46_ ITYLR 51_ GLFPE 56_ SSYGE 61_ RHLDD 66_ LSLKI 71_ LREDK 76_ KCPGS 81_ LHIIR 86_ WIQGC 91_ FDALE 96_ KRYLR 101_ MAVLT 106_ LYTDP 111_ MGSEK 116_ VTEMY 121_ QFKFK 126_ YTKEG 131_ ATMDF 136_ DSHSS 141_ STSFE 146_ SGTNN 151_ EDIKK 156_ ASVLL 161_ IRKLY 166_ ILMQD 171_ LEPLP 176_ NNVVL 181_ TMKLH 186_ YYNAV 191_ TPHDY 196_ QPLGF 201_ KEGVN 206_ SHFLL 211_ FDKEP 216_ INVQV 221_ GFVST 226_ GFHSM 231_ KVKVM 236_ TEATK 241_ VIDLE 246_ NNLFR 251_ ENSTT 256_ EIAHQ 261_ GLDCD 266_ EEEEC 271_ NDHIQ 276_ RMNFV 281_ CSQQS 286_ SECSR 291_ KKRKV 296_ SEPVK 301_VFIPN
1: Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity)