APC membrane recruitment protein 2 (Amer2) (Protein FAM123A)
1_METSR 6_ SRGGG 11_ GAVSE 16_ RGGAG 21_ ASVGV 26_ CRRKA 31_ EAGAG 36_ TGTLA 41_ ADMDL 46_ HCDCA 51_ AETPA 56_ AEPPS 61_ GKINK 66_ AAFKL 71_ FKKRK 76_ SGGTM 81_ PSIFG 86_ VKNKG 91_ DGKSS 96_ GPTGL 101_ VRSRT 106_ HDGLA 111_ EVLVL 116_ ESGRK 121_ EEPRG 126_ GGDSG 131_ GGGGG 136_ RPNPG 141_ PPRAA 146_ GPGGG 151_ SLASS 156_ SVAKS 161_ HSFFS 166_ LLKKN 171_ GRSEN 176_ GKGEP 181_ VDASK 186_ AGGKQ 191_ KRGLR 196_ GLFSG 201_ MRWHR 206_ KDKRA 211_ KAEAA 216_ EGRAP 221_ GGGLI 226_ LPGSL 231_ TASLE 236_ CVKEE 241_ TPRAA 246_ REPEE 251_ PSQDA 256_ PRDPA 261_ GEPAG 266_ GEEVP 271_ APADR 276_ APARS 281_ CREAE 286_ GLAHP 291_ GDTGA 296_ RGEDA 301_ AGHRR 306_ AEPGP 311_ GEVRT 316_ AEDAS 321_ RTGAV 326_ PVKTV 331_ PLVDS 336_ EGGSG 341_ RAPAA 346_ PDPAS 351_ VDPPS 356_ DPSAD 361_ RICLM 366_ FSDVT 371_ SLKSF 376_ DSLTG 381_ CGDII 386_ ADQEE 391_ EAGPS 396_ CDKHV 401_ PGPGK 406_ PALSK 411_ KNPGV 416_ VAYQG 421_ GGEEM 426_ ASPDE 431_ VDDTY 436_ LQEFW 441_ DMLSQ 446_ TEEQG 451_ PEPQE 456_ GAAKV 461_ AAALE 466_ TKVVP 471_ ETPKD 476_ TRCVE 481_ AAKDA 486_ SSVKR 491_ RRLNR 496_ IPIEP 501_ HPKEE 506_ PKHPE 511_ KEQQE 516_ GVPNS 521_ DEGYW 526_ DSTTP 531_ GPEED 536_ SSSSG 541_ KKAGI 546_ PRDSY 551_ SGDAL 556_ YDLYA 561_ DPDGS 566_ PATLP 571_ GGKDN 576_ EETSS 581_ LSRLK 586_ PVSPG 591_ TITCP 596_ LRTPG 601_ SLLKD 606_ SKIPI 611_ SIKHL 616_ TNLPS 621_ SHPVV 626_ HQQPS 631_ RSEMP 636_ RTKIP 641_ VSKVL 646_ VRRVS 651_ NRGLA 656_ GTTIR 661_ ATACH 666_DSAKK
1: Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex