Cyclin N-terminal domain-containing protein 1
1_MDGPM 6_ RPRSA 11_ SLVDF 16_ QFGVV 21_ ATETI 26_ EDALL 31_ HLAQQ 36_ NEQAV 41_ REASG 46_ RLGRF 51_ REPQI 56_ VEFVF 61_ LLSEQ 66_ WCLEK 71_ SVSYQ 76_ AVEIL 81_ ERFMV 86_ KQAEN 91_ ICRQA 96_ TIQPR 101_ DNKRE 106_ SQNWR 111_ ALKQQ 116_ LVNKF 121_ TLRLV 126_ SCVQL 131_ ASKLS 136_ FRNKI 141_ ISNIT 146_ VLNFL 151_ QALGY 156_ LHTKE 161_ ELLES 166_ ELDVL 171_ KSLNF 176_ RINLP 181_ TPLAY 186_ VETLL 191_ EVLGY 196_ NGCLV 201_ PAMRL 206_ HATCL 211_ TLLDL 216_ VYLLH 221_ EPIYE 226_ SLLRA 231_ SIENS 236_ TPSQL 241_ QGEKF 246_ TSVKE 251_ DFMLL 256_ AVGII 261_ AASAF 266_ IQNHE 271_ CWSQV 276_ VGHLQ 281_ SITGI 286_ ALASI 291_ AEFSY 296_ AILTH 301_ GVGAN 306_ TPGRQ 311_ QSIPP 316_ HLAAR 321_ALKTV
1: Plays a role in the different steps of crossover formation during meiotic recombination. Participates in the crossover differentiation step of crossover-specific recombination intermediates through its interaction with PRR19. In addition, stimulates crossover formation through the interactions with RFC3 and RFC4 and simultaneously regulates cell-cycle progression through interactions with CDC34 and subsequent ubiquitination of WEE1. May also participates in an active deselection process that destabilizes or removes excess pre-CO intermediates