Tubulin polyglutamylase TTLL6 (EC 6.3.2.-) (Protein polyglutamylase TTLL6) (Tubulin--tyrosine ligase-like protein 6)
1_MPQCP 6_ TLESQ 11_ EGENS 16_ EEKGD 21_ SSKED 26_ PKETV 31_ ALAFV 36_ RENPG 41_ AQNGL 46_ QNAQQ 51_ QGKKK 56_ RKKKR 61_ LVINL 66_ SSCRY 71_ ESVRR 76_ AAQQY 81_ GFREG 86_ GEDDD 91_ WTLYW 96_ TDYSV 101_ SLERV 106_ MEMKS 111_ YQKIN 116_ HFPGM 121_ SEICR 126_ KDLLA 131_ RNMSR 136_ MLKMF 141_ PKDFR 146_ FFPRT 151_ WCLPA 156_ DWGDL 161_ QTYSR 166_ SRKNK 171_ TYICK 176_ PDSGC 181_ QGKGI 186_ FITRT 191_ VKEIK 196_ PGEDM 201_ ICQLY 206_ ISKPF 211_ IIDGF 216_ KFDLR 221_ IYVLV 226_ TSCDP 231_ LRIFV 236_ YNEGL 241_ ARFAT 246_ TSYSR 251_ PCTDN 256_ LDDIC 261_ MHLTN 266_ YSINK 271_ HSSNF 276_ SRDAH 281_ SGSKR 286_ KLSTF 291_ SAYLE 296_ DHSYN 301_ VEQIW 306_ RDIED 311_ VIIKT 316_ LISAH 321_ PIIRH 326_ NYHTC 331_ FPNHT 336_ LNSAC 341_ FEILG 346_ FDILL 351_ DHKLK 356_ PWLLE 361_ VNHSP 366_ SFSTD 371_ SRLDK 376_ EVKDG 381_ LLYDT 386_ LVLIN 391_ LESCD 396_ KKKVL 401_ EEERQ 406_ RGQFL 411_ QQCCS 416_ REMRI 421_ EEAKG 426_ FRAVQ 431_ LKKTE 436_ TYEKE 441_ NCGGF 446_ RLIYP 451_ SLNSE 456_ KYEKF 461_ FQDNN 466_ SLFQN 471_ TVASR 476_ AREEY 481_ ARQLI 486_ QELRL 491_ KREKK 496_ PFQMK 501_ KKVEM 506_ QGESA 511_ GEQVR 516_ KKGMR 521_ GWQQK 526_ QQQKD 531_ KAATQ 536_ ASKQY 541_ IQPLT 546_ LVSYT 551_ PDLLL 556_ SVRGE 561_ RKNET 566_ DSSLN 571_ QEAPT 576_ EEASS 581_ VFPKL 586_ TSAKP 591_ FSSLP 596_ DLRNI 601_ NLSSS 606_ KLEPS 611_ KPNFS 616_ IKEAK 621_ SASAV 626_ NVFTG 631_ TVHLT 636_ SVETT 641_ PESTT 646_ QLSIS 651_ PKSPP 656_ TLAVT 661_ ASSEY 666_ SGPET 671_ DRVVS 676_ FKCKK 681_ QQTPP 686_ HLTQK 691_ KMLKS 696_ FLPTK 701_ SKSFW 706_ ESPNT 711_ NWTLL 716_ KSDMN 721_ KPHLI 726_ SELLT 731_ KLQLS 736_ GKLSF 741_ FPAHY 746_ NPKLG 751_ MNNLS 756_ QNPSL 761_ PGECH 766_ SRSDS 771_ SGEKR 776_ QLDVS 781_ SLLLQ 786_ SPQSY 791_ NVTLR 796_ DLLVI 801_ ATPAQ 806_ LDPRP 811_ CRSHA 816_ SAMRD 821_ PCMQD 826_ QEAYS 831_ HCLIS 836_GQKGC
1: Polyglutamylase which modifies both tubulin and non-tubulin proteins, generating alpha-linked polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues of target proteins. Preferentially mediates ATP-dependent long polyglutamate chain elongation over the initiation step of the polyglutamylation reaction. Preferentially modifies the alpha-tubulin tail over a beta-tail. Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions. Mediates microtubule polyglutamylation in primary cilia axoneme, which is important for ciliary structural formation and motility. Mediates microtubule polyglutamylation in motile cilia, necessary for the regulation of ciliary coordinated beating. Polyglutamylates non-tubulin protein nucleotidyltransferase CGAS, leading to CGAS DNA-binding inhibition, thereby preventing antiviral defense response