E3 ubiquitin-protein ligase RNF152 (EC 2.3.2.27) (RING finger protein 152) (RING-type E3 ubiquitin transferase RNF152)
1_METLS 6_ QDSLL 11_ ECQIC 16_ FNYYS 21_ PRRRP 26_ KLLDC 31_ KHTCC 36_ SVCLQ 41_ QMRTS 46_ QKDVR 51_ CPWCR 56_ GVTKL 61_ PPGFS 66_ VSQLP 71_ DDPEV 76_ LAVIA 81_ IPHTS 86_ EHTPV 91_ FIKLP 96_ SNGCY 101_ MLPLP 106_ ISKER 111_ ALLPG 116_ DMGCR 121_ LLPGS 126_ QQKSV 131_ TVVTI 136_ PAEQQ 141_ PLQGG 146_ APQEA 151_ VEEEQ 156_ DRRGV 161_ VKSST 166_ WSGVC 171_ TVILV 176_ ACVLV 181_ FLLGI 186_ VLHNM 191_ SCISK 196_RFTVI
1: E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB (PubMed:25936802, PubMed:30514904). Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling (PubMed:25936802). Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition (PubMed:30514904). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation (PubMed:21203937). Induces apoptosis when overexpressed (PubMed:21203937)