Prostaglandin reductase 2 (PRG-2) (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase) (Zinc-binding alcohol dehydrogenase domain-containing protein 1)
1_MIVQR 6_ VVLNS 11_ RPGKN 16_ GNPVA 21_ ENFRM 26_ EEVYL 31_ PDNIN 36_ EGQVQ 41_ VRTLY 46_ LSVDP 51_ YMRCR 56_ MNEDT 61_ GTDYI 66_ TPWQL 71_ SQVVD 76_ GGGIG 81_ IIEES 86_ KHTNL 91_ TKGDF 96_ VTSFY 101_ WPWQT 106_ KVILD 111_ GNSLE 116_ KVDPQ 121_ LVDGH 126_ LSYFL 131_ GAIGM 136_ PGLTS 141_ LIGIQ 146_ EKGHI 151_ TAGSN 156_ KTMVV 161_ SGAAG 166_ ACGSV 171_ AGQIG 176_ HFLGC 181_ SRVVG 186_ ICGTH 191_ EKCIL 196_ LTSEL 201_ GFDAA 206_ INYKK 211_ DNVAE 216_ QLRES 221_ CPAGV 226_ DVYFD 231_ NVGGN 236_ ISDTV 241_ ISQMN 246_ ENSHI 251_ ILCGQ 256_ ISQYN 261_ KDVPY 266_ PPPLS 271_ PAIEA 276_ IQKER 281_ NITRE 286_ RFLVL 291_ NYKDK 296_ FEPGI 301_ LQLSQ 306_ WFKEG 311_ KLKIK 316_ ETVIN 321_ GLENM 326_ GAAFQ 331_ SMMTG 336_ GNIGK 341_ QIVCI 346_SEEIS
1: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2 (PubMed:19000823). Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity)