Endonuclease V (hEndoV) (EC 3.1.26.-) (Inosine-specific endoribonuclease)
1_MALEA 6_ AGGPP 11_ EETLS 16_ LWKRE 21_ QARLK 26_ AHVVD 31_ RDTEA 36_ WQRDP 41_ AFSGL 46_ QRVGG 51_ VDVSF 56_ VKGDS 61_ VRACA 66_ SLVVL 71_ SFPEL 76_ EVVYE 81_ ESRMV 86_ SLTAP 91_ YVSGF 96_ LAFRE 101_ VPFLL 106_ ELVQQ 111_ LREKE 116_ PGLMP 121_ QVLLV 126_ DGNGV 131_ LHHRG 136_ FGVAC 141_ HLGVL 146_ TDLPC 151_ VGVAK 156_ KLLQV 161_ DGLEN 166_ NALHK 171_ EKIRL 176_ LQTRG 181_ DSFPL 186_ LGDSG 191_ TVLGM 196_ ALRSH 201_ DRSTR 206_ PLYIS 211_ VGHRM 216_ SLEAA 221_ VRLTC 226_ CCCRF 231_ RIPEP 236_ VRQAD 241_ ICSRE 246_ HIRKS 251_ LGLPG 256_ PPTPR 261_ SPKAQ 266_ RPVAC 271_ PKGDS 276_GESSA
1: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:23912683, PubMed:23912718, PubMed:25195743, PubMed:27573237, PubMed:31703097). Active against both single-stranded and double-stranded RNAs (PubMed:25195743, PubMed:31703097). Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs) (PubMed:23912718). Cleaves mRNAs and tRNAs containing inosine (PubMed:23912683, PubMed:31703097). Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3' (PubMed:23912718, PubMed:27573237). Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing (Probable). Binds branched DNA structures (PubMed:23139746)
2: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:31703097). Active against both single-stranded and double-stranded RNAs (PubMed:31703097). Cleaves tRNAs containing inosine (PubMed:31703097)
3: Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine (PubMed:31703097). Active against both single-stranded and double-stranded RNAs (PubMed:31703097). Cleaves tRNAs containing inosine (PubMed:31703097)