DAN domain family member 5 (Cerberus-like protein 2) (Cerl-2) (Cysteine knot superfamily 1, BMP antagonist 3) (Gremlin-3)
1_MLLGQ 6_ LSTLL 11_ CLLSG 16_ ALPTG 21_ SGRPE 26_ PQSPR 31_ PQSWA 36_ AANQT 41_ WALGP 46_ GALPP 51_ LVPAS 56_ ALGSW 61_ KAFLG 66_ LQKAR 71_ QLGMG 76_ RLQRG 81_ QDEVA 86_ AVTLP 91_ LNPQE 96_ VIQGM 101_ CKAVP 106_ FVQVF 111_ SRPGC 116_ SAIRL 121_ RNHLC 126_ FGHCS 131_ SLYIP 136_ GSDPT 141_ PLVLC 146_ NSCMP 151_ ARKRW 156_ APVVL 161_ WCLTG 166_ SSASR 171_ RRVKI 176_ STMLI 181_EGCHC
1: Antagonist of the extracellular signaling protein NODAL, which is required for correct left-right patterning during embryonic development (By similarity). Antagonist of BMP and TGF-beta signaling (PubMed:33587337). Independently of its role in left-right axis establishment, plays a role during heart development, possibly through the regulation of TGF-beta/Nodal signaling pathway (By similarity). Displays anti-angiogenic activity by inhibiting endothelial sprouting, migration, and proliferation. Once internalized by endothelial cells, may alter their redox and glycolytic balance (PubMed:33587337)