Nuclear envelope phosphatase-regulatory subunit 1 (NEP1-R1) (Transmembrane protein 188)
1_MNSLE 6_ QAEDL 11_ KAFER 16_ RLTEY 21_ IHCLQ 26_ PATGR 31_ WRMLL 36_ IVVSV 41_ CTATG 46_ AWNWL 51_ IDPET 56_ QKVSF 61_ FTSLW 66_ NHPFF 71_ TISCI 76_ TLIGL 81_ FFAGI 86_ HKRVV 91_ APSII 96_ AARCR 101_ TVLAE 106_ YNMSC 111_ DDTGK 116_LILKP
1: Forms with the serine/threonine protein phosphatase CTDNEP1 an active complex which dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol