Junction-mediating and -regulatory protein
1_MSFAL 6_ EETLE 11_ SDWVA 16_ VRPHV 21_ FDERE 26_ KHKFV 31_ FIVAW 36_ NEIEG 41_ KFAIT 46_ CHNRT 51_ AQRQR 56_ SGSRE 61_ QAGAR 66_ GGAEA 71_ GGAAS 76_ DGSRG 81_ PGSPA 86_ GRGRP 91_ EATAS 96_ ATLVR 101_ SPGPR 106_ RSSAW 111_ AEGGS 116_ PRSTR 121_ SLLGD 126_ PRLRS 131_ PGSKG 136_ AESRL 141_ RSPVR 146_ AKPIP 151_ GQKTS 156_ EADDA 161_ AGAAA 166_ AAARP 171_ APREA 176_ QVSSV 181_ RIVSA 186_ SGTVS 191_ EEIEV 196_ LEMVK 201_ EDEAP 206_ LALSD 211_ AEQPP 216_ PATEL 221_ ESPAE 226_ ECSWA 231_ GLFSF 236_ QDLRA 241_ VHQQL 246_ CSVNS 251_ QLEPC 256_ LPVFP 261_ EEPSG 266_ MWTVL 271_ FGGAP 276_ EMTEQ 281_ EIDTL 286_ CYQLQ 291_ VYLGH 296_ GLDTC 301_ GWKIL 306_ SQVLF 311_ TETDD 316_ PEEYY 321_ ESLSE 326_ LRQKG 331_ YEEVL 336_ QRARK 341_ RIQEL 346_ LDKHK 351_ NTESM 356_ VELLD 361_ LYQME 366_ DEAYS 371_ SLAEA 376_ TTELY 381_ QYLLQ 386_ PFRDM 391_ RELAM 396_ LRRQQ 401_ IKISM 406_ ENDYL 411_ GPRRI 416_ ESLQK 421_ EDADW 426_ QRKAH 431_ MAVLS 436_ IQDLT 441_ VKYFE 446_ ITAKA 451_ QKAVY 456_ DRMRA 461_ DQKKF 466_ GKASW 471_ AAAAE 476_ RMEKL 481_ QYAVS 486_ KETLQ 491_ MMRAK 496_ EICLE 501_ QRKHA 506_ LKEEM 511_ QSLRG 516_ GTEAI 521_ ARLDQ 526_ LEADY 531_ YDLQL 536_ QLYEV 541_ QFEIL 546_ KCEEL 551_ LLTAQ 556_ LESIK 561_ RLISE 566_ KRDEV 571_ VYYDT 576_ YESME 581_ AMLEK 586_ EEMAA 591_ SAYLQ 596_ REELQ 601_ KLQQK 606_ ARQLE 611_ ARRGR 616_ VSAKK 621_ SYLRN 626_ KKEIC 631_ IAKHN 636_ EKIQQ 641_ RTRIE 646_ DEYRT 651_ HHTVQ 656_ LKREK 661_ LHDEE 666_ ERKSA 671_ WVSQE 676_ RQRTL 681_ DRLRT 686_ FKQRY 691_ PGQVI 696_ LKSTR 701_ LRLAH 706_ ARRKG 711_ AASPV 716_ LQEDH 721_ CDSLP 726_ SVLQV 731_ EEKTE 736_ EVGEG 741_ RVKRG 746_ PSQTT 751_ EPQSL 756_ VQLED 761_ TSLTQ 766_ LEATS 771_ LPLSG 776_ VTSEL 781_ PPTIS 786_ LPLLN 791_ NNLEP 796_ CSVTI 801_ NPLPS 806_ PLPPT 811_ PPPPP 816_ PPPPP 821_ PPPPP 826_ LPVAK 831_ DSGPE 836_ TLEKD 841_ LPRKE 846_ GNEKR 851_ IPKSA 856_ SAPSA 861_ HLFDS 866_ SQLVS 871_ ARKKL 876_ RKTAE 881_ GLQRR 886_ RVSSP 891_ MDEVL 896_ ASLKR 901_ GSFHL 906_ KKVEQ 911_ RTLPP 916_ FPDED 921_ DSNNI 926_ LAQIR 931_ KGVKL 936_ KKVQK 941_ DVLRE 946_ SFTLL 951_ PDTDP 956_ LTRSI 961_ HEALR 966_ RIKEA 971_ SPESE 976_ DEEEA 981_LPCTD
1: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions (PubMed:30420355). In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments (PubMed:30420355). Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments (PubMed:30420355). Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. Upon nutrient stress, directly recruited by MAP1LC3B to the phagophore membrane surfaces to promote actin assembly during autophagy (PubMed:30420355). The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location (By similarity)