Lysophospholipase D GDPD1 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 4) (Glycerophosphodiester phosphodiesterase domain-containing protein 1)
1_MSSTA 6_ AFYLL 11_ STLGG 16_ YLVTS 21_ FLLLK 26_ YPTLL 31_ HQRKK 36_ QRFLS 41_ KHISH 46_ RGGAG 51_ ENLEN 56_ TMAAF 61_ QHAVK 66_ IGTDM 71_ LELDC 76_ HITKD 81_ EQVVV 86_ SHDEN 91_ LKRAT 96_ GVNVN 101_ ISDLK 106_ YCELP 111_ PYLGK 116_ LDVSF 121_ QRACQ 126_ CEGKD 131_ NRIPL 136_ LKEVF 141_ EAFPN 146_ TPINI 151_ DIKVN 156_ NNVLI 161_ KKVSE 166_ LVKRY 171_ NREHL 176_ TVWGN 181_ ANYEI 186_ VEKCY 191_ KENSD 196_ IPILF 201_ SLQRV 206_ LLILG 211_ LFFTG 216_ LLPFV 221_ PIREQ 226_ FFEIP 231_ MPSII 236_ LKLKE 241_ PHTMS 246_ RSQKF 251_ LIWLS 256_ DLLLM 261_ RKALF 266_ DHLTA 271_ RGIQV 276_ YIWVL 281_ NEEQE 286_ YKRAF 291_ DLGAT 296_ GVMTD 301_ YPTKL 306_RDFLH
1: Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines (PubMed:25596343, PubMed:27637550). Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC) (PubMed:25596343, PubMed:27637550). May be involved in bioactive N-acylethanolamine biosynthesis from both N-acyl-lysoplasmenylethanolamin (N-acyl-lysoPlsEt) and N-acyl-lysophosphatidylethanolamin (N-acyl-lysoPE) (PubMed:25596343, PubMed:27637550). In addition, hydrolyzes glycerophospho-N-acylethanolamine to N-acylethanolamine (PubMed:27637550). Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine (By similarity)