Probable E3 ubiquitin-protein ligase DTX3 (EC 2.3.2.27) (Protein deltex-3) (Deltex3) (RING finger protein 154) (RING-type E3 ubiquitin transferase DTX3)
1_MSFVL 6_ SRMAA 11_ CGGTC 16_ KNKVT 21_ VSKPV 26_ WDFLS 31_ KETPA 36_ RLARL 41_ REEHR 46_ VSILI 51_ DGETS 56_ DIYVL 61_ QLSPQ 66_ GPPPA 71_ PPNGL 76_ YLARK 81_ ALKGL 86_ LKEAE 91_ KELKK 96_ AQRQG 101_ ELMGC 106_ LALGG 111_ GGEHP 116_ EMHRA 121_ GPPPL 126_ RAAPL 131_ LPPGA 136_ RGLPP 141_ PPPPL 146_ PPPLP 151_ PRLRE 156_ EAEEQ 161_ ESTCP 166_ ICLGE 171_ IQNAK 176_ TLEKC 181_ RHSFC 186_ EGCIT 191_ RALQV 196_ KKACP 201_ MCGRF 206_ YGQLV 211_ GNQPQ 216_ NGRML 221_ VSKDA 226_ TLLLP 231_ SYEKY 236_ GTIVI 241_ QYVFP 246_ PGVQG 251_ AEHPN 256_ PGVRY 261_ PGTTR 266_ VAYLP 271_ DCPEG 276_ NKVLT 281_ LFRKA 286_ FDQRL 291_ TFTIG 296_ TSMTT 301_ GRPNV 306_ ITWND 311_ IHHKT 316_ SCTGG 321_ PQLFG 326_ YPDPT 331_ YLTRV 336_ QEELR 341_AKGIT
1: Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity