Sodium-dependent lysophosphatidylcholine symporter 1 (NLS1) (Sodium-dependent LPC symporter 1) (Major facilitator superfamily domain-containing protein 2A) (HsMFSD2A)
1_MAKGE 6_ GAESG 11_ SAAGL 16_ LPTSI 21_ LQSTE 26_ RPAQV 31_ KKEPK 36_ KKKQQ 41_ LSVCN 46_ KLCYA 51_ LGGAP 56_ YQVTG 61_ CALGF 66_ FLQIY 71_ LLDVA 76_ QKDEE 81_ VVFCF 86_ SSFQV 91_ GPFSA 96_ SIILF 101_ VGRAW 106_ DAITD 111_ PLVGL 116_ CISKS 121_ PWTCL 126_ GRLMP 131_ WIIFS 136_ TPLAV 141_ IAYFL 146_ IWFVP 151_ DFPHG 156_ QTYWY 161_ LLFYC 166_ LFETM 171_ VTCFH 176_ VPYSA 181_ LTMFI 186_ STEQT 191_ ERDSA 196_ TAYRM 201_ TVEVL 206_ GTVLG 211_ TAIQG 216_ QIVGQ 221_ ADTPC 226_ FQDLN 231_ SSTVA 236_ SQSAN 241_ HTHGT 246_ TSHRE 251_ TQKAY 256_ LLAAG 261_ VIVCI 266_ YIICA 271_ VILIL 276_ GVREQ 281_ REPYE 286_ AQQSE 291_ PIAYF 296_ RGLRL 301_ VMSHG 306_ PYIKL 311_ ITGFL 316_ FTSLA 321_ FMLVE 326_ GNFVL 331_ FCTYT 336_ LGFRN 341_ EFQNL 346_ LLAIM 351_ LSATL 356_ TIPIW 361_ QWFLT 366_ RFGKK 371_ TAVYV 376_ GISSA 381_ VPFLI 386_ LVALM 391_ ESNLI 396_ ITYAV 401_ AVAAG 406_ ISVAA 411_ AFLLP 416_ WSMLP 421_ DVIDD 426_ FHLKQ 431_ PHFHG 436_ TEPIF 441_ FSFYV 446_ FFTKF 451_ ASGVS 456_ LGIST 461_ LSLDF 466_ AGYQT 471_ RGCSQ 476_ PERVK 481_ FTLNM 486_ LVTMA 491_ PIVLI 496_ LLGLL 501_ LFKMY 506_ PIDEE 511_ RRRQN 516_ KKALQ 521_ ALRDE 526_ ASSSG 531_ CSETD 536_STELA
1: Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (PubMed:24828040, PubMed:32572202, PubMed:34135507). Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain (By similarity). Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain (PubMed:26005868, PubMed:34135507). Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons (By similarity). Does not transport docosahexaenoic acid in unesterified fatty acid (By similarity). Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). Not required for central nervous system vascular morphogenesis (By similarity). Acts as a transporter for tunicamycin, an inhibitor of asparagine-linked glycosylation (PubMed:21677192). In placenta, acts as a receptor for ERVFRD-1/syncytin-2 and is required for trophoblast fusion (PubMed:18988732, PubMed:23177091)