Poly(A)-specific ribonuclease PNLDC1 (EC 3.1.13.4) (PARN-like domain-containing protein 1) (Poly(A)-specific ribonuclease domain-containing protein 1) (HsPNLDC1)
1_MFCTR 6_ GLLFF 11_ AFLAG 16_ LDIEF 21_ TGLRS 26_ NLSGP 31_ QQISL 36_ FDLPS 41_ EWYLK 46_ TRQSV 51_ QQFTV 56_ CQIGL 61_ SVFSA 66_ IEGEA 71_ NKYIA 76_ HSCNF 81_ YLFPT 86_ TFGIL 91_ DSEFS 96_ FQASS 101_ VQFLN 106_ QYGFN 111_ YNKFL 116_ KNGIP 121_ YMNEE 126_ QEKKI 131_ RHDIL 136_ TGNWR 141_ VRSSP 146_ DKDQI 151_ KVVID 156_ EVTRW 161_ LELAK 166_ EGDWM 171_ TLPGI 176_ TGFQA 181_ FEVQL 186_ VLRQA 191_ LPNIW 196_ TVLKD 201_ EGVVV 206_ KKVSK 211_ QHRWY 216_ LQNTS 221_ CDRES 226_ CWKEN 231_ ILLSA 236_ RGFSV 241_ FFQML 246_ VKAQK 251_ PLVGH 256_ NMMMD 261_ LLHLH 266_ EKFFR 271_ PLPES 276_ YDQFK 281_ QNIHS 286_ LFPVL 291_ IDTKS 296_ VTKDI 301_ WKEMN 306_ FPRVS 311_ NLSEV 316_ YEVLN 321_ SDLNP 326_ TKNSG 331_ PEIVH 336_ ASRCE 341_ KYVET 346_ KCPHE 351_ AAYDA 356_ FLCGS 361_ VLLKV 366_ AHLLL 371_ QKIYH 376_ IDPVP 381_ ESSFP 386_ QYLDV 391_ LAPYV 396_ NQVNL 401_ IRAGV 406_ PKINF 411_ SGPDY 416_ PSIRP 421_ PILIL 426_ SVKRW 431_ PGVSE 436_ QQVYH 441_ KFQNL 446_ CKFDV 451_ RRLTR 456_ SQFLL 461_ LTNKF 466_ KDARN 471_ ILKEY 476_ RDHPT 481_ LCISL 486_ YRYWR 491_ HSPNV 496_ NCLLQ 501_ VCGIV 506_ TAWAL 511_LAFIL
1: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512). May act as a regulator of multipotency in embryonic stem cells (By similarity). Is a critical factor for proper spermatogenesis, involved in pre-piRNAs processing to generate mature piRNAs (PubMed:34347949)