Interleukin-17 receptor C (IL-17 receptor C) (IL-17RC) (Interleukin-17 receptor homolog) (IL17Rhom) (Interleukin-17 receptor-like protein) (IL-17RL) (ZcytoR14)
1_MPVPW 6_ FLLSL 11_ ALGRS 16_ PVVLS 21_ LERLV 26_ GPQDA 31_ THCSP 36_ VSLEP 41_ WGDEE 46_ RLRVQ 51_ FLAQQ 56_ SLSLA 61_ PVTAA 66_ TARTA 71_ LSGLS 76_ GADGR 81_ REERG 86_ RGKSW 91_ VCLSL 96_ GGSGN 101_ TEPQK 106_ KGLSC 111_ RLWDS 116_ DILCL 121_ PGDIV 126_ PAPGP 131_ VLAPT 136_ HLQTE 141_ LVLRC 146_ QKETD 151_ CDLCL 156_ RVAVH 161_ LAVHG 166_ HWEEP 171_ EDEEK 176_ FGGAA 181_ DSGVE 186_ EPRNA 191_ SLQAQ 196_ VVLSF 201_ QAYPT 206_ ARCVL 211_ LEVQV 216_ PAALV 221_ QFGQS 226_ VGSVV 231_ YDCFE 236_ AALGS 241_ EVRIW 246_ SYTQP 251_ RYEKE 256_ LNHTQ 261_ QLPDC 266_ RGLEV 271_ WNSIP 276_ SCWAL 281_ PWLNV 286_ SADGD 291_ NVHLV 296_ LNVSE 301_ EQHFG 306_ LSLYW 311_ NQVQG 316_ PPKPR 321_ WHKNL 326_ TGPQI 331_ ITLNH 336_ TDLVP 341_ CLCIQ 346_ VWPLE 351_ PDSVR 356_ TNICP 361_ FREDP 366_ RAHQN 371_ LWQAA 376_ RLQLL 381_ TLQSW 386_ LLDAP 391_ CSLPA 396_ EAALC 401_ WRAPG 406_ GDPCQ 411_ PLVPP 416_ LSWEN 421_ VTVDK 426_ VLEFP 431_ LLKGH 436_ PNLCV 441_ QVNSS 446_ EKLQL 451_ QECLW 456_ ADSLG 461_ PLKDD 466_ VLLLE 471_ TRGPQ 476_ DNRSL 481_ CALEP 486_ SGCTS 491_ LPSKA 496_ STRAA 501_ RLGEY 506_ LLQDL 511_ QSGQC 516_ LQLWD 521_ DDLGA 526_ LWACP 531_ MDKYI 536_ HKRWA 541_ LVWLA 546_ CLLFA 551_ AALSL 556_ ILLLK 561_ KDHAK 566_ GWLRL 571_ LKQDV 576_ RSGAA 581_ ARGRA 586_ ALLLY 591_ SADDS 596_ GFERL 601_ VGALA 606_ SALCQ 611_ LPLRV 616_ AVDLW 621_ SRREL 626_ SAQGP 631_ VAWFH 636_ AQRRQ 641_ TLQEG 646_ GVVVL 651_ LFSPG 656_ AVALC 661_ SEWLQ 666_ DGVSG 671_ PGAHG 676_ PHDAF 681_ RASLS 686_ CVLPD 691_ FLQGR 696_ APGSY 701_ VGACF 706_ DRLLH 711_ PDAVP 716_ ALFRT 721_ VPVFT 726_ LPSQL 731_ PDFLG 736_ ALQQP 741_ RAPRS 746_ GRLQE 751_ RAEQV 756_ SRALQ 761_ PALDS 766_ YFHPP 771_ GTPAP 776_ GRGVG 781_ PGAGP 786_GAGDG
1: Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (By similarity). Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:16785495, PubMed:32187518). Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (By similarity). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:17911633, PubMed:18684971). Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity)
2: Receptor for both IL17A and IL17F
3: Does not bind IL17A or IL17F
4: Does not bind IL17A or IL17F
5: Receptor for both IL17A and IL17F