Histone-lysine N-methyltransferase SMYD1 (EC 2.1.1.354) (SET and MYND domain-containing protein 1)
1_MTIGR 6_ MENVE 11_ VFTAE 16_ GKGRG 21_ LKATK 26_ EFWAA 31_ DIIFA 36_ ERAYS 41_ AVVFD 46_ SLVNF 51_ VCHTC 56_ FKRQE 61_ KLHRC 66_ GQCKF 71_ AHYCD 76_ RTCQK 81_ DAWLN 86_ HKNEC 91_ SAIKR 96_ YGKVP 101_ NENIR 106_ LAARI 111_ MWRVE 116_ REGTG 121_ LTEGC 126_ LVSVD 131_ DLQNH 136_ VEHFG 141_ EEEQK 146_ DLRVD 151_ VDTFL 156_ QYWPP 161_ QSQQF 166_ SMQYI 171_ SHIFG 176_ VINCN 181_ GFTLS 186_ DQRGL 191_ QAVGV 196_ GIFPN 201_ LGLVN 206_ HDCWP 211_ NCTVI 216_ FNNGN 221_ HEAVK 226_ SMFHT 231_ QMRIE 236_ LRALG 241_ KISEG 246_ EELTV 251_ SYIDF 256_ LNVSE 261_ ERKRQ 266_ LKKQY 271_ YFDCT 276_ CEHCQ 281_ KKLKD 286_ DLFLG 291_ VKDNP 296_ KPSQE 301_ VVKEM 306_ IQFSK 311_ DTLEK 316_ IDKAR 321_ SEGLY 326_ HEVVK 331_ LCREC 336_ LEKQE 341_ PVFAD 346_ TNIYM 351_ LRMLS 356_ IVSEV 361_ LSYLQ 366_ AFEEA 371_ SFYAR 376_ RMVDG 381_ YMKLY 386_ HPNNA 391_ QLGMA 396_ VMRAG 401_ LTNWH 406_ AGNIE 411_ VGHGM 416_ ICKAY 421_ AILLV 426_ THGPS 431_ HPITK 436_ DLEAM 441_ RVQTE 446_ MELRM 451_ FRQNE 456_ FMYYK 461_ MREAA 466_ LNNQP 471_ MQVMA 476_ EPSNE 481_PSPAL
1: Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis