Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.4.19.12) (Deubiquitinating enzyme 38) (HP43.8KD) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38)
1_MDKIL 6_ EGLVS 11_ SSHPL 16_ PLKRV 21_ IVRKV 26_ VESAE 31_ HWLDE 36_ AQCEA 41_ MFDLT 46_ TRLIL 51_ EGQDP 56_ FQRQV 61_ GHQVL 66_ EAYAR 71_ YHRPE 76_ FESFF 81_ NKTFV 86_ LGLLH 91_ QGYHS 96_ LDRKD 101_ VAILD 106_ YIHNG 111_ LKLIM 116_ SCPSV 121_ LDLFS 126_ LLQVE 131_ VLRMV 136_ CERPE 141_ PQLCA 146_ RLSDL 151_ LTDFV 156_ QCIPK 161_ GKLSI 166_ TFCQQ 171_ LVRTI 176_ GHFQC 181_ VSTQE 186_ RELRE 191_ YVSQV 196_ TKVSN 201_ LLQNI 206_ WKAEP 211_ ATLLP 216_ SLQEV 221_ FASIS 226_ STDAS 231_ FEPSV 236_ ALASL 241_ VQHIP 246_ LQMIT 251_ VLIRS 256_ LTTDP 261_ NVKDA 266_ SMTQA 271_ LCRMI 276_ DWLSW 281_ PLAQH 286_ VDTWV 291_ IALLK 296_ GLAAV 301_ QKFTI 306_ LIDVT 311_ LLKIE 316_ LVFNR 321_ LWFPL 326_ VRPGA 331_ LAVLS 336_ HMLLS 341_ FQHSP 346_ EAFHL 351_ IVPHV 356_ VNLVH 361_ SFKND 366_ GLPSS 371_ TAFLV 376_ QLTEL 381_ IHCMM 386_ YHYSG 391_ FPDLY 396_ EPILE 401_ AIKDF 406_ PKPSE 411_ EKIKL 416_ ILNQS 421_ AWTSQ 426_ SNSLA 431_ SCLSR 436_ LSGKS 441_ ETGKT 446_ GLINL 451_ GNTCY 456_ MNSVI 461_ QALFM 466_ ATDFR 471_ RQVLS 476_ LNLNG 481_ CNSLM 486_ KKLQH 491_ LFAFL 496_ AHTQR 501_ EAYAP 506_ RIFFE 511_ ASRPP 516_ WFTPR 521_ SQQDC 526_ SEYLR 531_ FLLDR 536_ LHEEE 541_ KILKV 546_ QASHK 551_ PSEIL 556_ ECSET 561_ SLQEV 566_ ASKAA 571_ VLTET 576_ PRTSD 581_ GEKTL 586_ IEKMF 591_ GGKLR 596_ THIRC 601_ LNCRS 606_ TSQKV 611_ EAFTD 616_ LSLAF 621_ CPSSS 626_ LENMS 631_ VQDPA 636_ SSPSI 641_ QDGGL 646_ MQASV 651_ PGPSE 656_ EPVVY 661_ NPTTA 666_ AFICD 671_ SLVNE 676_ KTIGS 681_ PPNEF 686_ YCSEN 691_ TSVPN 696_ ESNKI 701_ LVNKD 706_ VPQKP 711_ GGETT 716_ PSVTD 721_ LLNYF 726_ LAPEI 731_ LTGDN 736_ QYYCE 741_ NCASL 746_ QNAEK 751_ TMQIT 756_ EEPEY 761_ LILTL 766_ LRFSY 771_ DQKYH 776_ VRRKI 781_ LDNVS 786_ LPLVL 791_ ELPVK 796_ RITSF 801_ SSLSE 806_ SWSVD 811_ VDFTD 816_ LSENL 821_ AKKLK 826_ PSGTD 831_ EASCT 836_ KLVPY 841_ LLSSV 846_ VVHSG 851_ ISSES 856_ GHYYS 861_ YARNI 866_ TSTDS 871_ SYQMY 876_ HQSEA 881_ LALAS 886_ SQSHL 891_ LGRDS 896_ PSAVF 901_ EQDLE 906_ NKEMS 911_ KEWFL 916_ FNDSR 921_ VTFTS 926_ FQSVQ 931_ KITSR 936_ FPKDT 941_ AYVLL 946_ YKKQH 951_ STNGL 956_ SGNNP 961_ TSGLW 966_ INGDP 971_ PLQKE 976_ LMDAI 981_ TKDNK 986_ LYLQE 991_ QELNA 996_ RARAL 1001_ QAASA 1006_ SCSFR 1011_ PNGFD 1016_ DNDPP 1021_ GSCGP 1026_ TGGGG 1031_ GGGFN 1036_TVGRL
1: Deubiquitinating enzyme that plays a role in various cellular processes, including DNA repair, cell cycle regulation, and immune response (PubMed:22689415, PubMed:30497519, PubMed:31874856, PubMed:35238669). Plays a role in the inhibition of type I interferon signaling by mediating the 'Lys-33' to 'Lys-48' ubiquitination transition of TBK1 leading to its degradation (PubMed:27692986). Cleaves the ubiquitin chain from the histone demethylase LSD1/KDM1A and prevents it from degradation by the 26S proteasome, thus maintaining LSD1 protein level in cells (PubMed:30497519). Plays a role in the DNA damage response by regulating the deacetylase activity of HDAC1 (PubMed:31874856). Mechanistically, removes the 'Lys-63'-linked ubiquitin chain promoting the deacetylase activity of HDAC1 in response to DNA damage (PubMed:31874856). Also acts as a specific deubiquitinase of histone deacetylase 3/HDAC3 and cleaves its 'Lys-63'-linked ubiquitin chains to lower its histone deacetylase activity (PubMed:32404892). Regulates MYC levels and cell proliferation via antagonizing ubiquitin E3 ligase FBXW7 thereby preventing MYC 'Lys-48'-linked ubiquitination and degradation (PubMed:34102342). Participates in antiviral response by removing both 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of Zika virus envelope protein E (PubMed:34696459). Constitutively associated with IL-33R/IL1RL1, deconjugates its 'Lys-27'-linked polyubiquitination resulting in its autophagic degradation (PubMed:35238669)