Phospholipid-transporting ATPase IG (EC 7.6.2.1) (ATPase IQ) (ATPase class VI type 11C) (P4-ATPase flippase complex alpha subunit ATP11C)
1_MQMVP 6_ SLPPA 11_ SECAG 16_ EEKRV 21_ GTRTV 26_ FVGNH 31_ PVSET 36_ EAYIA 41_ QRFCD 46_ NRIVS 51_ SKYTL 56_ WNFLP 61_ KNLFE 66_ QFRRI 71_ ANFYF 76_ LIIFL 81_ VQVTV 86_ DTPTS 91_ PVTSG 96_ LPLFF 101_ VITVT 106_ AIKQG 111_ YEDCL 116_ RHRAD 121_ NEVNK 126_ STVYI 131_ IENAK 136_ RVRKE 141_ SEKIK 146_ VGDVV 151_ EVQAD 156_ ETFPC 161_ DLILL 166_ SSCTT 171_ DGTCY 176_ VTTAS 181_ LDGES 186_ NCKTH 191_ YAVRD 196_ TIALC 201_ TAESI 206_ DTLRA 211_ AIECE 216_ QPQPD 221_ LYKFV 226_ GRINI 231_ YSNSL 236_ EAVAR 241_ SLGPE 246_ NLLLK 251_ GATLK 256_ NTEKI 261_ YGVAV 266_ YTGME 271_ TKMAL 276_ NYQGK 281_ SQKRS 286_ AVEKS 291_ INAFL 296_ IVYLF 301_ ILLTK 306_ AAVCT 311_ TLKYV 316_ WQSTP 321_ YNDEP 326_ WYNQK 331_ TQKER 336_ ETLKV 341_ LKMFT 346_ DFLSF 351_ MVLFN 356_ FIIPV 361_ SMYVT 366_ VEMQK 371_ FLGSF 376_ FISWD 381_ KDFYD 386_ EEINE 391_ GALVN 396_ TSDLN 401_ EELGQ 406_ VDYVF 411_ TDKTG 416_ TLTEN 421_ SMEFI 426_ ECCID 431_ GHKYK 436_ GVTQE 441_ VDGLS 446_ QTDGT 451_ LTYFD 456_ KVDKN 461_ REELF 466_ LRALC 471_ LCHTV 476_ EIKTN 481_ DAVDG 486_ ATESA 491_ ELTYI 496_ SSSPD 501_ EIALV 506_ KGAKR 511_ YGFTF 516_ LGNRN 521_ GYMRV 526_ ENQRK 531_ EIEEY 536_ ELLHT 541_ LNFDA 546_ VRRRM 551_ SVIVK 556_ TQEGD 561_ ILLFC 566_ KGADS 571_ AVFPR 576_ VQNHE 581_ IELTK 586_ VHVER 591_ NAMDG 596_ YRTLC 601_ VAFKE 606_ IAPDD 611_ YERIN 616_ RQLIE 621_ AKMAL 626_ QDREE 631_ KMEKV 636_ FDDIE 641_ TNMNL 646_ IGATA 651_ VEDKL 656_ QDQAA 661_ ETIEA 666_ LHAAG 671_ LKVWV 676_ LTGDK 681_ METAK 686_ STCYA 691_ CRLFQ 696_ TNTEL 701_ LELTT 706_ KTIEE 711_ SERKE 716_ DRLHE 721_ LLIEY 726_ RKKLL 731_ HEFPK 736_ STRSF 741_ KKAWT 746_ EHQEY 751_ GLIID 756_ GSTLS 761_ LILNS 766_ SQDSS 771_ SNNYK 776_ SIFLQ 781_ ICMKC 786_ TAVLC 791_ CRMAP 796_ LQKAQ 801_ IVRMV 806_ KNLKG 811_ SPITL 816_ SIGDG 821_ ANDVS 826_ MILES 831_ HVGIG 836_ IKGKE 841_ GRQAA 846_ RNSDY 851_ SVPKF 856_ KHLKK 861_ LLLAH 866_ GHLYY 871_ VRIAH 876_ LVQYF 881_ FYKNL 886_ CFILP 891_ QFLYQ 896_ FFCGF 901_ SQQPL 906_ YDAAY 911_ LTMYN 916_ ICFTS 921_ LPILA 926_ YSLLE 931_ QHINI 936_ DTLTS 941_ DPRLY 946_ MKISG 951_ NAMLQ 956_ LGPFL 961_ YWTFL 966_ AAFEG 971_ TVFFF 976_ GTYFL 981_ FQTAS 986_ LEENG 991_ KVYGN 996_ WTFGT 1001_ IVFTV 1006_ LVFTV 1011_ TLKLA 1016_ LDTRF 1021_ WTWIN 1026_ HFVIW 1031_ GSLAF 1036_ YVFFS 1041_ FFWGG 1046_ IIWPF 1051_ LKQQR 1056_ MYFVF 1061_ AQMLS 1066_ SVSTW 1071_ LAIIL 1076_ LIFIS 1081_ LFPEI 1086_ LLIVL 1091_ KNVRR 1096_ RSARR 1101_ NLSCR 1106_ RASDS 1111_ LSARP 1116_ SVRPL 1121_ LLRTF 1126_SDESN
1: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:24904167, PubMed:25315773, PubMed:26567335, PubMed:32493773). Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages (PubMed:26944472). Required for B cell differentiation past the pro-B cell stage (By similarity). Seems to mediate PS flipping in pro-B cells (By similarity). May be involved in the transport of cholestatic bile acids (By similarity)