Lysine-specific histone demethylase 1B (EC 1.14.99.66) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 2)
1_MATPR 6_ GRTKK 11_ KASFD 16_ HSPDS 21_ LPLRS 26_ SGRQA 31_ KKKAT 36_ ETTDE 41_ DEDGG 46_ SEKKY 51_ RKCEK 56_ AGCTA 61_ TCPVC 66_ FASAS 71_ ERCAK 76_ NGYTS 81_ RWYHL 86_ SCGEH 91_ FCNEC 96_ FDHYY 101_ RSHKD 106_ GYDKY 111_ TTWKK 116_ IWTSN 121_ GKTEP 126_ SPKAF 131_ MADQQ 136_ LPYWV 141_ QCTKP 146_ ECRKW 151_ RQLTK 156_ EIQLT 161_ PQIAK 166_ TYRCG 171_ MKPNT 176_ AIKPE 181_ TSDHC 186_ SLPED 191_ LRVLE 196_ VSNHW 201_ WYSML 206_ ILPPL 211_ LKDSV 216_ AAPLL 221_ SAYYP 226_ DCVGM 231_ SPSCT 236_ STNRA 241_ AATGN 246_ ASPGK 251_ LEHSK 256_ AALSV 261_ HVPGM 266_ NRYFQ 271_ PFYQP 276_ NECGK 281_ ALCVR 286_ PDVME 291_ LDELY 296_ EFPEY 301_ SRDPT 306_ MYLAL 311_ RNLIL 316_ ALWYT 321_ NCKEA 326_ LTPQK 331_ CIPHI 336_ IVRGL 341_ VRIRC 346_ VQEVE 351_ RILYF 356_ MTRKG 361_ LINTG 366_ VLSVG 371_ ADQYL 376_ LPKDY 381_ HNKSV 386_ IIIGA 391_ GPAGL 396_ AAARQ 401_ LHNFG 406_ IKVTV 411_ LEAKD 416_ RIGGR 421_ VWDDK 426_ SFKGV 431_ TVGRG 436_ AQIVN 441_ GCINN 446_ PVALM 451_ CEQLG 456_ ISMHK 461_ FGERC 466_ DLIQE 471_ GGRIT 476_ DPTID 481_ KRMDF 486_ HFNAL 491_ LDVVS 496_ EWRKD 501_ KTQLQ 506_ DVPLG 511_ EKIEE 516_ IYKAF 521_ IKESG 526_ IQFSE 531_ LEGQV 536_ LQFHL 541_ SNLEY 546_ ACGSN 551_ LHQVS 556_ ARSWD 561_ HNEFF 566_ AQFAG 571_ DHTLL 576_ TPGYS 581_ VIIEK 586_ LAEGL 591_ DIQLK 596_ SPVQC 601_ IDYSG 606_ DEVQV 611_ TTTDG 616_ TGYSA 621_ QKVLV 626_ TVPLA 631_ LLQKG 636_ AIQFN 641_ PPLSE 646_ KKMKA 651_ INSLG 656_ AGIIE 661_ KIALQ 666_ FPYRF 671_ WDSKV 676_ QGADF 681_ FGHVP 686_ PSASK 691_ RGLFA 696_ VFYDM 701_ DPQKK 706_ HSVLM 711_ SVIAG 716_ EAVAS 721_ VRTLD 726_ DKQVL 731_ QQCMA 736_ TLREL 741_ FKEQE 746_ VPDPT 751_ KYFVT 756_ RWSTD 761_ PWIQM 766_ AYSFV 771_ KTGGS 776_ GEAYD 781_ IIAED 786_ IQGTV 791_ FFAGE 796_ ATNRH 801_ FPQTV 806_ TGAYL 811_ SGVRE 816_ASKIA
1: Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:30970244)