ATPase family protein 2 homolog (EC 3.6.4.10) (Spermatogenesis-associated factor protein) (Spermatogenesis-associated protein 5)
1_MSSKK 6_ NRKRL 11_ NQSAE 16_ NGSSL 21_ PSAAS 26_ SCAEA 31_ RAPSA 36_ GSDFA 41_ ATSGT 46_ LTVTN 51_ LLEKV 56_ DDKIP 61_ KTFQN 66_ SLIHL 71_ GLNTM 76_ KSANI 81_ CIGRP 86_ VLLTS 91_ LNGKQ 96_ EVYTA 101_ WPMAG 106_ FPGGK 111_ VGLSE 116_ MAQKN 121_ VGVRP 126_ GDAIQ 131_ VQPLV 136_ GAVLQ 141_ AEEMD 146_ VALSD 151_ KDMEI 156_ NEEEL 161_ TGCIL 166_ RKLDG 171_ KIVLP 176_ GNFLY 181_ CTFYG 186_ RPYKL 191_ QVLRV 196_ KGADG 201_ MILGG 206_ PQSDS 211_ DTDAQ 216_ RMAFE 221_ QSSME 226_ TSSLE 231_ LSLQL 236_ SQLDL 241_ EDTQI 246_ PTSRS 251_ TPYKP 256_ IDDRI 261_ TNKAS 266_ DVLLD 271_ VTQSP 276_ GDGSG 281_ LMLEE 286_ VTGLK 291_ CNFES 296_ AREGN 301_ EQLTE 306_ EERLL 311_ KFSIG 316_ AKCNT 321_ DTFYF 326_ ISSTT 331_ RVNFT 336_ EIDKN 341_ SKEQD 346_ NQFKV 351_ TYDMI 356_ GGLSS 361_ QLKAI 366_ REIIE 371_ LPLKQ 376_ PELFK 381_ SYGIP 386_ APRGV 391_ LLYGP 396_ PGTGK 401_ TMIAR 406_ AVANE 411_ VGAYV 416_ SVING 421_ PEIIS 426_ KFYGE 431_ TEAKL 436_ RQIFA 441_ EATLR 446_ HPSII 451_ FIDEL 456_ DALCP 461_ KREGA 466_ QNEVE 471_ KRVVA 476_ SLLTL 481_ MDGIG 486_ SEVSE 491_ GQVLV 496_ LGATN 501_ RPHAL 506_ DAALR 511_ RPGRF 516_ DKEIE 521_ IGVPN 526_ AQDRL 531_ DILQK 536_ LLRRV 541_ PHLLT 546_ EAELL 551_ QLANS 556_ AHGYV 561_ GADLK 566_ VLCNE 571_ AGLCA 576_ LRRIL 581_ KKQPN 586_ LPDVK 591_ VAGLV 596_ KITLK 601_ DFLQA 606_ MNDIR 611_ PSAMR 616_ EIAID 621_ VPNVS 626_ WSDIG 631_ GLESI 636_ KLKLE 641_ QAVEW 646_ PLKHP 651_ ESFIR 656_ MGIQP 661_ PKGVL 666_ LYGPP 671_ GCSKT 676_ MIAKA 681_ LANES 686_ GLNFL 691_ AIKGP 696_ ELMNK 701_ YVGES 706_ ERAVR 711_ ETFRK 716_ ARAVA 721_ PSIIF 726_ FDELD 731_ ALAVE 736_ RGSSL 741_ GAGNV 746_ ADRVL 751_ AQLLT 756_ EMDGI 761_ EQLKD 766_ VTILA 771_ ATNRP 776_ DRIDK 781_ ALMRP 786_ GRIDR 791_ IIYVP 796_ LPDAA 801_ TRREI 806_ FKLQF 811_ HSMPV 816_ SNEVD 821_ LDELI 826_ LQTDA 831_ YSGAE 836_ IVAVC 841_ REAAL 846_ LALEE 851_ DIQAN 856_ LIMKR 861_ HFTQA 866_ LSTVT 871_ PRIPE 876_ SLRRF 881_ YEDYQ 886_EKSGL
1: ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024, PubMed:38554706). May be involved in morphological and functional mitochondrial transformations during spermatogenesis (By similarity)