Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (EC 7.2.1.3) (Cytochrome b ascorbate-dependent protein 3) (Cytochrome b561 family member A3) (Lysosomal cytochrome b) (LCytb)
1_MVSGR 6_ FYLSC 11_ LLLGS 16_ LGSMC 21_ ILFTI 26_ YWMQY 31_ WRGGF 36_ AWNGS 41_ IYMFN 46_ WHPVL 51_ MVAGM 56_ VVFYG 61_ GASLV 66_ YRLPQ 71_ SWVGP 76_ KLPWK 81_ LLHAA 86_ LHLMA 91_ FVLTV 96_ VGLVA 101_ VFTFH 106_ NHGRT 111_ ANLYS 116_ LHSWL 121_ GITTV 126_ FLFAC 131_ QWFLG 136_ FAVFL 141_ LPWAS 146_ MWLRS 151_ LLKPI 156_ HVFFG 161_ AAILS 166_ LSIAS 171_ VISGI 176_ NEKLF 181_ FSLKN 186_ TTRPY 191_ HSLPS 196_ EAVFA 201_ NSTGM 206_ LVVAF 211_ GLLVL 216_ YILLA 221_ SSWKR 226_ PEPGI 231_ LTDRQ 236_PLLHD
1: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis