Draxin (Dorsal inhibitory axon guidance protein) (Dorsal repulsive axon guidance protein) (Neucrin)
1_MAGPA 6_ IHTAP 11_ MLFLV 16_ LLLPL 21_ ELSLA 26_ GALAP 31_ GTPAR 36_ NLPEN 41_ HIDLP 46_ GPALW 51_ TPQAS 56_ HHRRR 61_ GPGKK 66_ EWGPG 71_ LPSQA 76_ QDGAV 81_ VTATR 86_ QASRL 91_ PEAEG 96_ LLPEQ 101_ SPAGL 106_ LQDKD 111_ LLLGL 116_ ALPYP 121_ EKENR 126_ PPGWE 131_ RTRKR 136_ SREHK 141_ RRRDR 146_ LRLHQ 151_ GRALV 156_ RGPSS 161_ LMKKA 166_ ELSEA 171_ QVLDA 176_ AMEES 181_ STSLA 186_ PTMFF 191_ LTTFE 196_ AAPAT 201_ EESLI 206_ LPVTS 211_ LRPQQ 216_ AQPRS 221_ DGEVM 226_ PTLDM 231_ ALFDW 236_ TDYED 241_ LKPDG 246_ WPSAK 251_ KKEKH 256_ RGKLS 261_ SDGNE 266_ TSPAE 271_ GEPCD 276_ HHQDC 281_ LPGTC 286_ CDLRE 291_ HLCTP 296_ HNRGL 301_ NNKCF 306_ DDCMC 311_ VEGLR 316_ CYAKF 321_ HRNRR 326_ VTRRK 331_ GRCVE 336_ PETAN 341_GDQGS
1: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway