Formylglycine-generating enzyme (FGE) (EC 1.8.3.7) (C-alpha-formylglycine-generating enzyme 1) (Sulfatase-modifying factor 1)
1_MAAPA 6_ LGLVC 11_ GRCPE 16_ LGLVL 21_ LLLLL 26_ SLLCG 31_ AAGSQ 36_ EAGTG 41_ AGAGS 46_ LAGSC 51_ GCGTP 56_ QRPGA 61_ HGSSA 66_ AAHRY 71_ SREAN 76_ APGPV 81_ PGERQ 86_ LAHSK 91_ MVPIP 96_ AGVFT 101_ MGTDD 106_ PQIKQ 111_ DGEAP 116_ ARRVT 121_ IDAFY 126_ MDAYE 131_ VSNTE 136_ FEKFV 141_ NSTGY 146_ LTEAE 151_ KFGDS 156_ FVFEG 161_ MLSEQ 166_ VKTNI 171_ QQAVA 176_ AAPWW 181_ LPVKG 186_ ANWRH 191_ PEGPD 196_ STILH 201_ RPDHP 206_ VLHVS 211_ WNDAV 216_ AYCTW 221_ AGKRL 226_ PTEAE 231_ WEYSC 236_ RGGLH 241_ NRLFP 246_ WGNKL 251_ QPKGQ 256_ HYANI 261_ WQGEF 266_ PVTNT 271_ GEDGF 276_ QGTAP 281_ VDAFP 286_ PNGYG 291_ LYNIV 296_ GNAWE 301_ WTSDW 306_ WTVHH 311_ SVEET 316_ LNPKG 321_ PPSGK 326_ DRVKK 331_ GGSYM 336_ CHRSY 341_ CYRYR 346_ CAARS 351_ QNTPD 356_ SSASN 361_ LGFRC 366_AADRL
1: Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent (PubMed:12757706, PubMed:15657036, PubMed:15907468, PubMed:16368756, PubMed:21224894, PubMed:25931126). 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile (PubMed:12757706, PubMed:15657036, PubMed:15907468, PubMed:16368756, PubMed:25931126). Known substrates include GALNS, ARSA, STS and ARSE (PubMed:12757706, PubMed:15657036, PubMed:15907468)