Protein O-glucosyltransferase 1 (EC 2.4.1.376) (CAP10-like 46 kDa protein) (hCLP46) (KTEL motif-containing protein 1) (Myelodysplastic syndromes relative protein) (O-glucosyltransferase Rumi homolog) (hRumi) (Protein O-xylosyltransferase POGLUT1) (EC 2.4.2.63)
1_MEWWA 6_ SSPLR 11_ LWLLL 16_ FLLPS 21_ AQGRQ 26_ KESGS 31_ KWKVF 36_ IDQIN 41_ RSLEN 46_ YEPCS 51_ SQNCS 56_ CYHGV 61_ IEEDL 66_ TPFRG 71_ GISRK 76_ MMAEV 81_ VRRKL 86_ GTHYQ 91_ ITKNR 96_ LYREN 101_ DCMFP 106_ SRCSG 111_ VEHFI 116_ LEVIG 121_ RLPDM 126_ EMVIN 131_ VRDYP 136_ QVPKW 141_ MEPAI 146_ PVFSF 151_ SKTSE 156_ YHDIM 161_ YPAWT 166_ FWEGG 171_ PAVWP 176_ IYPTG 181_ LGRWD 186_ LFRED 191_ LVRSA 196_ AQWPW 201_ KKKNS 206_ TAYFR 211_ GSRTS 216_ PERDP 221_ LILLS 226_ RKNPK 231_ LVDAE 236_ YTKNQ 241_ AWKSM 246_ KDTLG 251_ KPAAK 256_ DVHLV 261_ DHCKY 266_ KYLFN 271_ FRGVA 276_ ASFRF 281_ KHLFL 286_ CGSLV 291_ FHVGD 296_ EWLEF 301_ FYPQL 306_ KPWVH 311_ YIPVK 316_ TDLSN 321_ VQELL 326_ QFVKA 331_ NDDVA 336_ QEIAE 341_ RGSQF 346_ IRNHL 351_ QMDDI 356_ TCYWE 361_ NLLSE 366_ YSKFL 371_ SYNVT 376_ RRKGY 381_ DQIIP 386_KMLKT
1: Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322). Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PubMed:21081508, PubMed:21490058, PubMed:21949356, PubMed:27807076, PubMed:28775322). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (PubMed:27807076). Notch glucosylation does not affect Notch ligand binding (PubMed:21490058). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity)