Aquaporin-11 (AQP-11)
1_MSPLL 6_ GLRSE 11_ LQDTC 16_ TSLGL 21_ MLSVV 26_ LLMGL 31_ ARVVA 36_ RQQLH 41_ RPVAH 46_ AFVLE 51_ FLATF 56_ QLCCC 61_ THELQ 66_ LLSEQ 71_ HPAHP 76_ TWTLT 81_ LVYFF 86_ SLVHG 91_ LTLVG 96_ TSSNP 101_ CGVMM 106_ QMMLG 111_ GMSPE 116_ TGAVR 121_ LLAQL 126_ VSALC 131_ SRYCT 136_ SALWS 141_ LGLTQ 146_ YHVSE 151_ RSFAC 156_ KNPIR 161_ VDLLK 166_ AVITE 171_ AVCSF 176_ LFHSA 181_ LLHFQ 186_ EVRTK 191_ LRIHL 196_ LAALI 201_ TFLVY 206_ AGGSL 211_ TGAVF 216_ NPALA 221_ LSLHF 226_ MCFDE 231_ AFPQF 236_ FIVYW 241_ LAPSL 246_ GILLM 251_ ILMFS 256_ FFLPW 261_ LHNNH 266_TINKK
1: Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain (PubMed:24845055, PubMed:24918044, PubMed:31546170). In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (PubMed:31546170). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (By similarity). Plays a role in the proximal tubule function by regulating its endosomal acidification (By similarity). May play a role in postnatal kidney development (By similarity)