Solute carrier family 4 member 11 (Sodium borate cotransporter 1) (NaBC1)
1_MAAAT 6_ RRVFH 11_ LQPCE 16_ NSPTM 21_ SQNGY 26_ FEDSS 31_ YYKCD 36_ TDDTF 41_ EAREE 46_ ILGDE 51_ AFDTA 56_ NSSIV 61_ SGESI 66_ RFFVN 71_ VNLEM 76_ QATNT 81_ ENEAT 86_ SGGCV 91_ LLHTS 96_ RKYLK 101_ LKNFK 106_ EEIRA 111_ HRDLD 116_ GFLAQ 121_ ASIVL 126_ NETAT 131_ SLDNV 136_ LRTML 141_ RRFAR 146_ DPDNN 151_ EPNCN 156_ LDLLM 161_ AMLFT 166_ DAGAP 171_ MRGKV 176_ HLLSD 181_ TIQGV 186_ TATVT 191_ GVRYQ 196_ QSWLC 201_ IICTM 206_ KALQK 211_ RHVCI 216_ SRLVR 221_ PQNWG 226_ ENSCE 231_ VRFVI 236_ LVLAP 241_ PKMKS 246_ TKTAM 251_ EVART 256_ FATMF 261_ SDIAF 266_ RQKLL 271_ ETRTE 276_ EEFKE 281_ ALVHQ 286_ RQLLT 291_ MVSHG 296_ PVAPR 301_ TKERS 306_ TVSLP 311_ AHRHP 316_ EPPKC 321_ KDFVP 326_ FGKGI 331_ REDIA 336_ RRFPL 341_ YPLDF 346_ TDGII 351_ GKNKA 356_ VGKYI 361_ TTTLF 366_ LYFAC 371_ LLPTI 376_ AFGSL 381_ NDENT 386_ DGAID 391_ VQKTI 396_ AGQSI 401_ GGLLY 406_ ALFSG 411_ QPLVI 416_ LLTTA 421_ PLALY 426_ IQVIR 431_ VICDD 436_ YDLDF 441_ NSFYA 446_ WTGLW 451_ NSFFL 456_ ALYAF 461_ FNLSL 466_ VMSLF 471_ KRSTE 476_ EIIAL 481_ FISIT 486_ FVLDA 491_ VKGTV 496_ KIFWK 501_ YYYGH 506_ YLDDY 511_ HTKRT 516_ SSLVS 521_ LSGLG 526_ ASLNA 531_ SLHTA 536_ LNASF 541_ LASPT 546_ ELPSA 551_ THSGQ 556_ ATAVL 561_ SLLIM 566_ LGTLW 571_ LGYTL 576_ YQFKK 581_ SPYLH 586_ PCVRE 591_ ILSDC 596_ ALPIA 601_ VLAFS 606_ LISSH 611_ GFREI 616_ EMSKF 621_ RYNPS 626_ ESPFA 631_ MAQIQ 636_ SLSLR 641_ AVSGA 646_ MGLGF 651_ LLSML 656_ FFIEQ 661_ NLVAA 666_ LVNAP 671_ ENRLV 676_ KGTAY 681_ HWDLL 686_ LLAII 691_ NTGLS 696_ LFGLP 701_ WIHAA 706_ YPHSP 711_ LHVRA 716_ LALVE 721_ ERVEN 726_ GHIYD 731_ TIVNV 736_ KETRL 741_ TSLGA 746_ SVLVG 751_ LSLLL 756_ LPVPL 761_ QWIPK 766_ PVLYG 771_ LFLYI 776_ ALTSL 781_ DGNQL 786_ VQRVA 791_ LLLKE 796_ QTAYP 801_ PTHYI 806_ RRVPQ 811_ RKIHY 816_ FTGLQ 821_ VLQLL 826_ LLCAF 831_ GMSSL 836_ PYMKM 841_ IFPLI 846_ MIAMI 851_ PIRYI 856_ LLPRI 861_ IEAKY 866_LDVMD
1: Multifunctional transporter with an impact in cell morphology and differentiation. In the presence of borate B(OH)4(-), acts as a voltage-dependent electrogenic Na(+)-coupled B(OH)4(-) cotransporter controlling boron homeostasis (PubMed:15525507). At early stages of stem cell differentiation, participates in synergy with ITGA5-ITGB1 and ITGAV-ITGB3 integrins and BMPR1A to promote cell adhesion and contractility that drives differentiation toward osteogenic commitment while inhibiting adipogenesis (By similarity). In the absence of B(OH)4(-), acts as a Na(+)-coupled OH(-) or H(+) permeable channel with implications in cellular redox balance (PubMed:15525507, PubMed:28642546). Regulates the oxidative stress response in corneal endothelium by enhancing antioxidant defenses and protecting cells from reactive oxygen species (PubMed:28642546). In response to hypo-osmotic challenge, also acts as a water permeable channel at the basolateral cell membrane of corneal endothelial cells and facilitates transendothelial fluid reabsorption in the aqueous humor (PubMed:23813972, PubMed:25007886, PubMed:31273259). In the presence of ammonia, acts as an electrogenic NH3/H(+) cotransporter and may play a role in ammonia transport and reabsorption in renal Henle's loop epithelium (PubMed:27581649)