Kinetochore protein Spc24 (hSpc24)
1_MAAFR 6_ DIEEV 11_ SQGLL 16_ SLLGA 21_ NRAEA 26_ QQRRL 31_ LGRHE 36_ QVVER 41_ LLETQ 46_ DGAEK 51_ QLREI 56_ LTMEK 61_ EVAQS 66_ LLNAK 71_ EQVHQ 76_ GGVEL 81_ QQLEA 86_ GLQEA 91_ GEEDT 96_ RLKAS 101_ LLQLT 106_ RELEE 111_ LKEIE 116_ ADLER 121_ QEKEV 126_ DEDTT 131_ VTIPS 136_ AVYVA 141_ QLYHQ 146_ VSKIE 151_ WDYEC 156_ EPGMV 161_ KGIHH 166_ GPSVA 171_ QPIHL 176_ DSTQL 181_ SRKFI 186_ SDYLW 191_SLVDT
1: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020)