Outer mitochondrial transmembrane helix translocase (EC 7.4.2.-) (ATPase family AAA domain-containing protein 1) (hATAD1) (Thorase)
1_MVHAE 6_ AFSRP 11_ LSRNE 16_ VVGLI 21_ FRLTI 26_ FGAVT 31_ YFTIK 36_ WMVDA 41_ IDPTR 46_ KQKVE 51_ AQKQA 56_ EKLMK 61_ QIGVK 66_ NVKLS 71_ EYEMS 76_ IAAHL 81_ VDPLN 86_ MHVTW 91_ SDIAG 96_ LDDVI 101_ TDLKD 106_ TVILP 111_ IKKKH 116_ LFENS 121_ RLLQP 126_ PKGVL 131_ LYGPP 136_ GCGKT 141_ LIAKA 146_ TAKEA 151_ GCRFI 156_ NLQPS 161_ TLTDK 166_ WYGES 171_ QKLAA 176_ AVFSL 181_ AIKLQ 186_ PSIIF 191_ IDEID 196_ SFLRN 201_ RSSSD 206_ HEATA 211_ MMKAQ 216_ FMSLW 221_ DGLDT 226_ DHSCQ 231_ VIVMG 236_ ATNRP 241_ QDLDS 246_ AIMRR 251_ MPTRF 256_ HINQP 261_ ALKQR 266_ EAILK 271_ LILKN 276_ ENVDR 281_ HVDLL 286_ EVAQE 291_ TDGFS 296_ GSDLK 301_ EMCRD 306_ AALLC 311_ VREYV 316_ NSTSE 321_ ESHDE 326_ DEIRP 331_ VQQQD 336_ LHRAI 341_ EKMKK 346_ SKDAA 351_ FQNVL 356_THVCL
1: Outer mitochondrial translocase required to remove mislocalized tail-anchored transmembrane proteins on mitochondria (PubMed:24843043). Specifically recognizes and binds tail-anchored transmembrane proteins: acts as a dislocase that mediates the ATP-dependent extraction of mistargeted tail-anchored transmembrane proteins from the mitochondrion outer membrane (By similarity). Also plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory (By similarity). Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity)