Sodium-coupled neutral amino acid transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11)
1_MANMN 6_ SDSRH 11_ LGTSE 16_ VDHER 21_ DPGPM 26_ NIQFE 31_ PSDLR 36_ SKRPF 41_ CIEPT 46_ NIVNV 51_ NHVIQ 56_ RVSDH 61_ ASAMN 66_ KRIHY 71_ YSRLT 76_ TPADK 81_ ALIAP 86_ DHVVP 91_ APEEC 96_ YVYSP 101_ LGSAY 106_ KLQSY 111_ TEGYG 116_ KNTSL 121_ VTIFM 126_ IWNTM 131_ MGTSI 136_ LSIPW 141_ GIKQA 146_ GFTTG 151_ MCVII 156_ LMGLL 161_ TLYCC 166_ YRVVK 171_ SRTMM 176_ FSLDT 181_ TSWEY 186_ PDVCR 191_ HYFGS 196_ FGQWS 201_ SLLFS 206_ LVSLI 211_ GAMIV 216_ YWVLM 221_ SNFLF 226_ NTGKF 231_ IFNFI 236_ HHIND 241_ TDTIL 246_ STNNS 251_ NPVIC 256_ PSAGS 261_ GGHPD 266_ NSSMI 271_ FYAND 276_ TGAQQ 281_ FEKWW 286_ DKSRT 291_ VPFYL 296_ VGLLL 301_ PLLNF 306_ KSPSF 311_ FSKFN 316_ ILGTV 321_ SVLYL 326_ IFLVT 331_ FKAVR 336_ LGFHL 341_ EFHWF 346_ IPTEF 351_ FVPEI 356_ RFQFP 361_ QLTGV 366_ LTLAF 371_ FIHNC 376_ IITLL 381_ KNNKK 386_ QENNV 391_ RDLCI 396_ AYMLV 401_ TLTYL 406_ YIGVL 411_ VFASF 416_ PSPPL 421_ SKDCI 426_ EQNFL 431_ DNFPS 436_ SDTLS 441_ FIARI 446_ FLLFQ 451_ MMTVY 456_ PLLGY 461_ LARVQ 466_ LLGHI 471_ FGDIY 476_ PSIFH 481_ VLILN 486_ LIIVG 491_ AGVIM 496_ ACFYP 501_ NIGGI 506_ IRYSG 511_ AACGL 516_ AFVFI 521_ YPSLI 526_ YIISL 531_ HQEER 536_ LTWPK 541_ LIFHV 546_ FIIIL 551_ GVANL 556_IVQFF
1: Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels (PubMed:25561175, PubMed:25567906, PubMed:29053970). Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:25567906, PubMed:29053970). Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:25561175, PubMed:25567906). SLC38A9 mediates transport of amino acids with low capacity and specificity with a slight preference for polar amino acids (PubMed:25561175, PubMed:25567906). Acts as an arginine sensor (PubMed:25567906, PubMed:29053970, PubMed:31295473). Following activation by arginine binding, mediates transport of L-glutamine, leucine and tyrosine with high efficiency, and is required for the efficient utilization of these amino acids after lysosomal protein degradation (PubMed:29053970, PubMed:31295473). However, the transport mechanism is not well defined and the role of sodium is not clear (PubMed:25561175, PubMed:31295473). Can disassemble the lysosomal folliculin complex (LFC), and thereby triggers GAP activity of FLCN:FNIP2 toward RRAGC (PubMed:32868926). Acts as an cholesterol sensor that conveys increases in lysosomal cholesterol, leading to lysosomal recruitment and activation of mTORC1 via the Rag GTPases (PubMed:28336668). Guanine exchange factor (GEF) that, upon arginine binding, stimulates GDP release from RRAGA and therefore activates the Rag GTPase heterodimer and the mTORC1 pathway in response to nutrient sufficiency (PubMed:30181260)