Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA-binding protein 1) (PAI-RBP1) (SERPINE1 mRNA-binding protein 1)
1_MPGHL 6_ QEGFG 11_ CVVTN 16_ RFDQL 21_ FDDES 26_ DPFEV 31_ LKAAE 36_ NKKKE 41_ AGGGG 46_ VGGPG 51_ AKSAA 56_ QAAAQ 61_ TNSNA 66_ AGKQL 71_ RKESQ 76_ KDRKN 81_ PLPPS 86_ VGVVD 91_ KKEET 96_ QPPVA 101_ LKKEG 106_ IRRVG 111_ RRPDQ 116_ QLQGE 121_ GKIID 126_ RRPER 131_ RPPRE 136_ RRFEK 141_ PLEEK 146_ GEGGE 151_ FSVDR 156_ PIIDR 161_ PIRGR 166_ GGLGR 171_ GRGGR 176_ GRGMG 181_ RGDGF 186_ DSRGK 191_ REFDR 196_ HSGSD 201_ RSSFS 206_ HYSGL 211_ KHEDK 216_ RGGSG 221_ SHNWG 226_ TVKDE 231_ LTESP 236_ KYIQK 241_ QISYN 246_ YSDLD 251_ QSNVT 256_ EETPE 261_ GEEHH 266_ PVADT 271_ ENKEN 276_ EVEEV 281_ KEEGP 286_ KEMTL 291_ DEWKA 296_ IQNKD 301_ RAKVE 306_ FNIRK 311_ PNEGA 316_ DGQWK 321_ KGFVL 326_ HKSKS 331_ EEAHA 336_ EDSVM 341_ DHHFR 346_ KPAND 351_ ITSQL 356_ EINFG 361_ DLGRP 366_ GRGGR 371_ GGRGG 376_ RGRGG 381_ RPNRG 386_ SRTDK 391_ SSASA 396_ PDVDD 401_PEAFP
1: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:36691768). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (PubMed:11001948). Seems to play a role in PML-nuclear bodies formation (PubMed:28695742)