LEM domain-containing protein 2 (hLEM2)
1_MAGLS 6_ DLELR 11_ RELQA 16_ LGFQP 21_ GPITD 26_ TTRDV 31_ YRNKL 36_ RRLRG 41_ EARLR 46_ DEERL 51_ REEAR 56_ PRGEE 61_ RLREE 66_ ARLRE 71_ DAPLR 76_ ARPAA 81_ ASPRA 86_ EPWLS 91_ QPASG 96_ SAYAT 101_ PGAYG 106_ DIRPS 111_ AASWV 116_ GSRGL 121_ AYPAR 126_ PAQLR 131_ RRASV 136_ RGSSE 141_ EDEDA 146_ RTPDR 151_ ATQGP 156_ GLAAR 161_ RWWAA 166_ SPAPA 171_ RLPSS 176_ LLGPD 181_ PRPGL 186_ RATRA 191_ GPAGA 196_ ARARP 201_ EVGRR 206_ LERWL 211_ SRLLL 216_ WASLG 221_ LLLVF 226_ LGILW 231_ VKMGK 236_ PSAPQ 241_ EAEDN 246_ MKLLP 251_ VDCER 256_ KTDEF 261_ CQAKQ 266_ KAALL 271_ ELLHE 276_ LYNFL 281_ AIQAG 286_ NFECG 291_ NPENL 296_ KSKCI 301_ PVMEA 306_ QEYIA 311_ NVTSS 316_ SSAKF 321_ EAALT 326_ WILSS 331_ NKDVG 336_ IWLKG 341_ EDQSE 346_ LVTTV 351_ DKVVC 356_ LESAH 361_ PRMGV 366_ GCRLS 371_ RALLT 376_ AVTNV 381_ LIFFW 386_ CLAFL 391_ WGLLI 396_ LLKYR 401_ WRKLE 406_ EEEQA 411_ MYEMV 416_ KKIID 421_ VVQDH 426_ YVDWE 431_ QDMER 436_ YPYVG 441_ ILHVR 446_ DSLIP 451_ PQSRR 456_ RMKRV 461_ WDRAV 466_ EFLAS 471_ NESRI 476_ QTESH 481_ RVAGE 486_ DMLVW 491_ RWTKP 496_SSFSD
1: Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization, maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967, PubMed:17097643, PubMed:28242692, PubMed:32494070). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (PubMed:28242692, PubMed:32494070). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (PubMed:28242692). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (PubMed:32494070). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (By similarity). Required for embryonic development and involved in regulation of several signaling pathways such as MAPK and AKT (By similarity). Required for myoblast differentiation involving regulation of ERK signaling (By similarity). Essential for cardiac homeostasis and proper heart function (By similarity)