Neuropilin and tolloid-like protein 2 (Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2)
1_MALER 6_ LCSVL 11_ KVLLI 16_ TVLVV 21_ EGIAV 26_ AQKTQ 31_ DGQNI 36_ GIKHI 41_ PATQC 46_ GIWVR 51_ TSNGG 56_ HFASP 61_ NYPDS 66_ YPPNK 71_ ECIYI 76_ LEAAP 81_ RQRIE 86_ LTFDE 91_ HYYIE 96_ PSFEC 101_ RFDHL 106_ EVRDG 111_ PFGFS 116_ PLIDR 121_ YCGVK 126_ SPPLI 131_ RSTGR 136_ FMWIK 141_ FSSDE 146_ ELEGL 151_ GFRAK 156_ YSFIP 161_ DPDFT 166_ YLGGI 171_ LNPIP 176_ DCQFE 181_ LSGAD 186_ GIVRS 191_ SQVEQ 196_ EEKTK 201_ PGQAV 206_ DCIWT 211_ IKATP 216_ KAKIY 221_ LRFLD 226_ YQMEH 231_ SNECK 236_ RNFVA 241_ VYDGS 246_ SSIEN 251_ LKAKF 256_ CSTVA 261_ NDVML 266_ KTGIG 271_ VIRMW 276_ ADEGS 281_ RLSRF 286_ RMLFT 291_ SFVEP 296_ PCTSS 301_ TFFCH 306_ SNMCI 311_ NNSLV 316_ CNGVQ 321_ NCAYP 326_ WDENH 331_ CKEKK 336_ KAGVF 341_ EQITK 346_ THGTI 351_ IGITS 356_ GIVLV 361_ LLIIS 366_ ILVQV 371_ KQPRK 376_ KVMAC 381_ KTAFN 386_ KTGFQ 391_ EVFDP 396_ PHYEL 401_ FSLRD 406_ KEISA 411_ DLADL 416_ SEELD 421_ NYQKM 426_ RRSST 431_ ASRCI 436_ HDHHC 441_ GSQAS 446_ SVKQS 451_ RTNLS 456_ SMELP 461_ FRNDF 466_ AQPQP 471_ MKTFN 476_ STFKK 481_ SSYTF 486_ KQGHE 491_ CPEQA 496_ LEDRV 501_ MEEIP 506_ CEIYV 511_ RGRED 516_SAQAS
1: Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity)