BTB/POZ domain-containing protein KCTD6 (KCASH3 protein) (Potassium channel tetramerization domain-containing protein 6)
1_MDNGD 6_ WGYMM 11_ TDPVT 16_ LNVGG 21_ HLYTT 26_ SLTTL 31_ TRYPD 36_ SMLGA 41_ MFGGD 46_ FPTAR 51_ DPQGN 56_ YFIDR 61_ DGPLF 66_ RYVLN 71_ FLRTS 76_ ELTLP 81_ LDFKE 86_ FDLLR 91_ KEADF 96_ YQIEP 101_ LIQCL 106_ NDPKP 111_ LYPMD 116_ TFEEV 121_ VELSS 126_ TRKLS 131_ KYSNP 136_ VAVII 141_ TQLTI 146_ TTKVH 151_ SLLEG 156_ ISNYF 161_ TKWNK 166_ HMMDT 171_ RDCQV 176_ SFTFG 181_ PCDYH 186_ QEVSL 191_ RVHLM 196_ EYITK 201_ QGFTI 206_ RNTRV 211_ HHMSE 216_ RANEN 221_ TVEHN 226_ WTFCR 231_LARKT
1: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887)