Phospholipase A2 group XV (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (EC 3.1.1.5) (Lysophospholipase 3) (Lysosomal phospholipase A and acyltransferase) (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (Lysosomal phospholipase A2) (LPLA2)
1_MGLHL 6_ RPYRV 11_ GLLPD 16_ GLLFL 21_ LLLLM 26_ LLADP 31_ ALPAG 36_ RHPPV 41_ VLVPG 46_ DLGNQ 51_ LEAKL 56_ DKPTV 61_ VHYLC 66_ SKKTE 71_ SYFTI 76_ WLNLE 81_ LLLPV 86_ IIDCW 91_ IDNIR 96_ LVYNK 101_ TSRAT 106_ QFPDG 111_ VDVRV 116_ PGFGK 121_ TFSLE 126_ FLDPS 131_ KSSVG 136_ SYFHT 141_ MVESL 146_ VGWGY 151_ TRGED 156_ VRGAP 161_ YDWRR 166_ APNEN 171_ GPYFL 176_ ALREM 181_ IEEMY 186_ QLYGG 191_ PVVLV 196_ AHSMG 201_ NMYTL 206_ YFLQR 211_ QPQAW 216_ KDKYI 221_ RAFVS 226_ LGAPW 231_ GGVAK 236_ TLRVL 241_ ASGDN 246_ NRIPV 251_ IGPLK 256_ IREQQ 261_ RSAVS 266_ TSWLL 271_ PYNYT 276_ WSPEK 281_ VFVQT 286_ PTINY 291_ TLRDY 296_ RKFFQ 301_ DIGFE 306_ DGWLM 311_ RQDTE 316_ GLVEA 321_ TMPPG 326_ VQLHC 331_ LYGTG 336_ VPTPD 341_ SFYYE 346_ SFPDR 351_ DPKIC 356_ FGDGD 361_ GTVNL 366_ KSALQ 371_ CQAWQ 376_ SRQEH 381_ QVLLQ 386_ ELPGS 391_ EHIEM 396_ LANAT 401_ TLAYL 406_KRVLL
1: Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:10092508, PubMed:11790796, PubMed:20410020, PubMed:23958596, PubMed:25727495, PubMed:29724779). Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity) (PubMed:10092508, PubMed:11790796, PubMed:20410020, PubMed:23958596, PubMed:25727495, PubMed:29724779, PubMed:36823305). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines (PubMed:29724779, PubMed:36823305). Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines, phosphatidylethanolamines, and phosphatidylglycerols (PubMed:36823305). Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (PubMed:29724779). Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress (PubMed:30830753). Required for normal phospholipid degradation in alveolar macrophages with potential implications in the clearance of pulmonary surfactant, which is mainly composed of dipalmitoylphosphatidylcholine (1,2-dihexadecanoyl-sn-glycero-3-phosphocholine) (By similarity). Involved in the first step of bis(monoacylglycero)phosphate (BMP) de novo synthesis from phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (PubMed:36823305). BMP is an important player in cargo sorting and degradation, regulation of cellular cholesterol levels and intercellular communication (PubMed:36823305). At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (PubMed:10092508)