NFATC2-interacting protein (45 kDa NF-AT-interacting protein) (45 kDa NFAT-interacting protein) (Nuclear factor of activated T-cells, cytoplasmic 2-interacting protein)
1_MAEPV 6_ GKRGR 11_ WSGGS 16_ GAGRG 21_ GRGGW 26_ GGRGR 31_ RPRAQ 36_ RSPSR 41_ GTLDV 46_ VSVDL 51_ VTDSD 56_ EEILE 61_ VATAR 66_ GAADE 71_ VEVEP 76_ PEPPG 81_ PVASR 86_ DNSNS 91_ DSEGE 96_ DRRPA 101_ GPPRE 106_ PVRRR 111_ RRLVL 116_ DPGEA 121_ PLVPV 126_ YSGKV 131_ KSSLR 136_ LIPDD 141_ LSLLK 146_ LYPPG 151_ DEEEA 156_ ELADS 161_ SGLYH 166_ EGSPS 171_ PGSPW 176_ KTKLR 181_ TKDKE 186_ EKKKT 191_ EFLDL 196_ DNSPL 201_ SPPSP 206_ RTKSR 211_ THTRA 216_ LKKLS 221_ EVNKR 226_ LQDLR 231_ SCLSP 236_ KPPQG 241_ QEQQG 246_ QEDEV 251_ VLVEG 256_ PTLPE 261_ TPRLF 266_ PLKIR 271_ CRADL 276_ VRLPL 281_ RMSEP 286_ LQSVV 291_ DHMAT 296_ HLGVS 301_ PSRIL 306_ LLFGE 311_ TELSP 316_ TATPR 321_ TLKLG 326_ VADII 331_ DCVVL 336_ TSSPE 341_ ATETS 346_ QQLQL 351_ RVQGK 356_ EKHQT 361_ LEVSL 366_ SRDSP 371_ LKTLM 376_ SHYEE 381_ AMGLS 386_ GRKLS 391_ FFFDG 396_ TKLSG 401_ RELPA 406_ DLGME 411_SGDLI
1: In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity)