Diacylglycerol lipase-beta (DAGL-beta) (DGL-beta) (EC 3.1.1.116) (KCCR13L) (PUFA-specific triacylglycerol lipase) (EC 3.1.1.3) (Sn1-specific diacylglycerol lipase beta)
1_MPGMV 6_ LFGRR 11_ WAIAS 16_ DDLVF 21_ PGFFE 26_ LVVRV 31_ LWWIG 36_ ILTLY 41_ LMHRG 46_ KLDCA 51_ GGALL 56_ SSYLI 61_ VLMIL 66_ LAVVI 71_ CTVSA 76_ IMCVS 81_ MRGTI 86_ CNPGP 91_ RKSMS 96_ KLLYI 101_ RLALF 106_ FPEMV 111_ WASLG 116_ AAWVA 121_ DGVQC 126_ DRTVV 131_ NGIIA 136_ TVVVS 141_ WIIIA 146_ ATVVS 151_ IIIVF 156_ DPLGG 161_ KMAPY 166_ SSAGP 171_ SHLDS 176_ HDSSQ 181_ LLNGL 186_ KTAAT 191_ SVWET 196_ RIKLL 201_ CCCIG 206_ KDDHT 211_ RVAFS 216_ STAEL 221_ FSTYF 226_ SDTDL 231_ VPSDI 236_ AAGLA 241_ LLHQQ 246_ QDNIR 251_ NNQEP 256_ AQVVC 261_ HAPGS 266_ SQEAD 271_ LDAEL 276_ ENCHH 281_ YMQFA 286_ AAAYG 291_ WPLYI 296_ YRNPL 301_ TGLCR 306_ IGGDC 311_ CRSRT 316_ TDYDL 321_ VGGDQ 326_ LNCHF 331_ GSILH 336_ TTGLQ 341_ YRDFI 346_ HVSFH 351_ DKVYE 356_ LPFLV 361_ ALDHR 366_ KESVV 371_ VAVRG 376_ TMSLQ 381_ DVLTD 386_ LSAES 391_ EVLDV 396_ ECEVQ 401_ DRLAH 406_ KGISQ 411_ AARYV 416_ YQRLI 421_ NDGIL 426_ SQAFS 431_ IAPEY 436_ RLVIV 441_ GHSLG 446_ GGAAA 451_ LLATM 456_ LRAAY 461_ PQVRC 466_ YAFSP 471_ PRGLW 476_ SKALQ 481_ EYSQS 486_ FIVSL 491_ VLGKD 496_ VIPRL 501_ SVTNL 506_ EDLKR 511_ RILRV 516_ VAHCN 521_ KPKYK 526_ ILLHG 531_ LWYEL 536_ FGGNP 541_ NNLPT 546_ ELDGG 551_ DQEVL 556_ TQPLL 561_ GEQSL 566_ LTRWS 571_ PAYSF 576_ SSDSP 581_ LDSSP 586_ KYPPL 591_ YPPGR 596_ IIHLQ 601_ EEGAS 606_ GRFGC 611_ CSAAH 616_ YSAKW 621_ SHEAE 626_ FSKIL 631_ IGPKM 636_ LTDHM 641_ PDILM 646_ RALDS 651_ VVSDR 656_ AACVS 661_ CPAQG 666_VSSVD
1: Lipase that catalyzes the hydrolysis of arachidonic acid (AA)-esterified diacylglycerols (DAGs) to produce the principal endocannabinoid, 2-arachidonoylglycerol (2-AG) which can be further cleaved by downstream enzymes to release arachidonic acid (AA) for cyclooxygenase (COX)-mediated eicosanoid production (PubMed:14610053). Preferentially hydrolyzes DAGs at the sn-1 position in a calcium-dependent manner and has negligible activity against other lipids including monoacylglycerols and phospholipids (PubMed:14610053). Plays a key role in the regulation of 2-AG and AA pools utilized by COX1/2 to generate lipid mediators of macrophage and microglia inflammatory responses. Also functions as a polyunsaturated fatty acids-specific triacylglycerol lipase in macrophages. Plays an important role to support the metabolic and signaling demands of macrophages (By similarity)