Potassium voltage-gated channel subfamily H member 5 (Ether-a-go-go potassium channel 2) (hEAG2) (Voltage-gated potassium channel subunit Kv10.2)
1_MPGGK 6_ RGLVA 11_ PQNTF 16_ LENIV 21_ RRSSE 26_ SSFLL 31_ GNAQI 36_ VDWPV 41_ VYSND 46_ GFCKL 51_ SGYHR 56_ ADVMQ 61_ KSSTC 66_ SFMYG 71_ ELTDK 76_ KTIEK 81_ VRQTF 86_ DNYES 91_ NCFEV 96_ LLYKK 101_ NRTPV 106_ WFYMQ 111_ IAPIR 116_ NEHEK 121_ VVLFL 126_ CTFKD 131_ ITLFK 136_ QPIED 141_ DSTKG 146_ WTKFA 151_ RLTRA 156_ LTNSR 161_ SVLQQ 166_ LTPMN 171_ KTEVV 176_ HKHSR 181_ LAEVL 186_ QLGSD 191_ ILPQY 196_ KQEAP 201_ KTPPH 206_ IILHY 211_ CAFKT 216_ TWDWV 221_ ILILT 226_ FYTAI 231_ MVPYN 236_ VSFKT 241_ KQNNI 246_ AWLVL 251_ DSVVD 256_ VIFLV 261_ DIVLN 266_ FHTTF 271_ VGPGG 276_ EVISD 281_ PKLIR 286_ MNYLK 291_ TWFVI 296_ DLLSC 301_ LPYDI 306_ INAFE 311_ NVDEG 316_ ISSLF 321_ SSLKV 326_ VRLLR 331_ LGRVA 336_ RKLDH 341_ YLEYG 346_ AAVLV 351_ LLVCV 356_ FGLVA 361_ HWLAC 366_ IWYSI 371_ GDYEV 376_ IDEVT 381_ NTIQI 386_ DSWLY 391_ QLALS 396_ IGTPY 401_ RYNTS 406_ AGIWE 411_ GGPSK 416_ DSLYV 421_ SSLYF 426_ TMTSL 431_ TTIGF 436_ GNIAP 441_ TTDVE 446_ KMFSV 451_ AMMMV 456_ GSLLY 461_ ATIFG 466_ NVTTI 471_ FQQMY 476_ ANTNR 481_ YHEML 486_ NNVRD 491_ FLKLY 496_ QVPKG 501_ LSERV 506_ MDYIV 511_ STWSM 516_ SKGID 521_ TEKVL 526_ SICPK 531_ DMRAD 536_ ICVHL 541_ NRKVF 546_ NEHPA 551_ FRLAS 556_ DGCLR 561_ ALAVE 566_ FQTIH 571_ CAPGD 576_ LIYHA 581_ GESVD 586_ ALCFV 591_ VSGSL 596_ EVIQD 601_ DEVVA 606_ ILGKG 611_ DVFGD 616_ IFWKE 621_ TTLAH 626_ ACANV 631_ RALTY 636_ CDLHI 641_ IKREA 646_ LLKVL 651_ DFYTA 656_ FANSF 661_ SRNLT 666_ LTCNL 671_ RKRII 676_ FRKIS 681_ DVKKE 686_ EEERL 691_ RQKNE 696_ VTLSI 701_ PVDHP 706_ VRKLF 711_ QKFKQ 716_ QKELR 721_ NQGST 726_ QGDPE 731_ RNQLQ 736_ VESRS 741_ LQNGA 746_ SITGT 751_ SVVTV 756_ SQITP 761_ IQTSL 766_ AYVKT 771_ SESLK 776_ QNNRD 781_ AMELK 786_ PNGGA 791_ DQKCL 796_ KVNSP 801_ IRMKN 806_ GNGKG 811_ WLRLK 816_ NNMGA 821_ HEEKK 826_ EDWNN 831_ VTKAE 836_ SMGLL 841_ SEDPK 846_ SSDSE 851_ NSVTK 856_ NPLRK 861_ TDSCD 866_ SGITK 871_ SDLRL 876_ DKAGE 881_ ARSPL 886_ EHSPI 891_ QADAK 896_ HPFYP 901_ IPEQA 906_ LQTTL 911_ QEVKH 916_ ELKED 921_ IQLLS 926_ CRMTA 931_ LEKQV 936_ AEILK 941_ ILSEK 946_ SVPQA 951_ SSPKS 956_ QMPLQ 961_ VPPQI 966_ PCQDI 971_ FSVSR 976_ PESPE 981_SDKDE
1: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate (PubMed:11943152, PubMed:12135768, PubMed:24133262, PubMed:36928654). The kinetic is characterized by a slow activation time course and a small voltage dependence of the activation time constants, therefore, starts to open at more negative voltages (PubMed:11943152, PubMed:12135768). The activation kinetics depend on the prepulse potential and external divalent cation concentration (PubMed:11943152, PubMed:24133262). The time course of activation is biphasic with a fast and a slowly activating current component (PubMed:11943152, PubMed:12135768, PubMed:36928654). With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation, therefore the activation rate depends on holding potential (PubMed:11943152, PubMed:12135768, PubMed:36928654)