Arrestin domain-containing protein 4
1_MGGEA 6_ GCAAA 11_ VGAEG 16_ RVKSL 21_ GLVFE 26_ DERKG 31_ CYSSG 36_ ETVAG 41_ HVLLE 46_ ASEPV 51_ ALRAL 56_ RLEAQ 61_ GRATA 66_ AWGPS 71_ TCPRA 76_ SASTA 81_ ALAVF 86_ SEVEY 91_ LNVRL 96_ SLREP 101_ PAGEG 106_ IILLQ 111_ PGKHE 116_ FPFRF 121_ QLPSE 126_ PLVTS 131_ FTGKY 136_ GSIQY 141_ CVRAV 146_ LERPK 151_ VPDQS 156_ VKREL 161_ QVVSH 166_ VDVNT 171_ PALLT 176_ PVLKT 181_ QEKMV 186_ GCWFF 191_ TSGPV 196_ SLSAK 201_ IERKG 206_ YCNGE 211_ AIPIY 216_ AEIEN 221_ CSSRL 226_ IVPKA 231_ AIFQT 236_ QTYLA 241_ SGKTK 246_ TIRHM 251_ VANVR 256_ GNHIA 261_ SGSTD 266_ TWNGK 271_ TLKIP 276_ PVTPS 281_ ILDCC 286_ IIRVD 291_ YSLAV 296_ YIHIP 301_ GAKKL 306_ MLELP 311_ LVIGT 316_ IPYNG 321_ FGSRN 326_ SSIAS 331_ QFSMD 336_ MSWLT 341_ LTLPE 346_ QPEAP 351_ PNYAD 356_ VVSEE 361_ EFSRH 366_ IPPYP 371_ QPPNC 376_ EGEVC 381_ CPVFA 386_ CIQEF 391_ RFQPP 396_ PLYSE 401_ VDPHP 406_ SDVEE 411_SQPVS
1: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake (PubMed:19605364). Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65 (PubMed:28594402)