Kremen protein 2 (Dickkopf receptor 2) (Kringle domain-containing transmembrane protein 2) (Kringle-containing protein marking the eye and the nose)
1_MGTQA 6_ LQGFL 11_ FLLFL 16_ PLLQP 21_ RGASA 26_ GSLHS 31_ PGLSE 36_ CFQVN 41_ GADYR 46_ GHQNR 51_ TGPRG 56_ AGRPC 61_ LFWDQ 66_ TQQHS 71_ YSSAS 76_ DPHGR 81_ WGLGA 86_ HNFCR 91_ NPDGD 96_ VQPWC 101_ YVAET 106_ EEGIY 111_ WRYCD 116_ IPSCH 121_ MPGYL 126_ GCFVD 131_ SGAPP 136_ ALSGP 141_ SGTST 146_ KLTVQ 151_ VCLRF 156_ CRMKG 161_ YQLAG 166_ VEAGY 171_ ACFCG 176_ SESDL 181_ ARGRL 186_ APATD 191_ CDQIC 196_ FGHPG 201_ QLCGG 206_ DGRLG 211_ VYEVS 216_ VGSCQ 221_ GNWTA 226_ PQGVI 231_ YSPDF 236_ PDEYG 241_ PDRNC 246_ SWALG 251_ PPGAA 256_ LELTF 261_ RLFEL 266_ ADPRD 271_ RLELR 276_ DAASG 281_ SLLRA 286_ FDGAR 291_ PPPSG 296_ PLRLG 301_ TAALL 306_ LTFRS 311_ DARGH 316_ AQGFA 321_ LTYRG 326_ LQDAA 331_ EDPEA 336_ PEGSA 341_ QTPAA 346_ PLDGA 351_ NVSCS 356_ PRPGA 361_ PPAAI 366_ GARVF 371_ STVTA 376_ VSVLL 381_ LLLLG 386_ LLRPL 391_ RRRSC 396_ LLAPG 401_ KGPPA 406_ LGASR 411_ GPRRS 416_ WAVWY 421_ QQPRG 426_ VALPC 431_ SPGDP 436_ QAEGS 441_ AAGYR 446_ PLSAS 451_ SQSSL 456_RSLIS
1: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation